2009 Fiscal Year Final Research Report
Molecular physiology toward making non-regressing corpus luteum in the cow
| Project/Area Number |
19380154
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
MIYAMOTO Akio Obihiro University of Agriculture and Veterinary Medicine, 畜産学部, 教授 (10192767)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Takashi 国立大学法人帯広畜産大学, 畜産学部, 准教授 (90375113)
MATSUI Motozumi 国立大学法人帯広畜産大学, 畜産学部, 准教授 (20374762)
SHIRASUNA Koumei 国立大学法人帯広畜産大学, 畜産学部, 助教 (20552780)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 黄体 / 退行 / PGF_<2α> / 血管機能 / データベース / ウシ |
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| Research Abstract |
Establishment of pregnancy is a basic phenomenon for the conserved strategy of species. In mammals, progesterone released from the corpus luteum has an essential key to establish pregnancy. The aim of the present study is to elucidate molecular mechanisms of development and regression of the bovine corpus luteum, and to give the new vision of the developing technologies for improvement of conception rate in the cow. From the results of the present study, we clearly showed that PGF_<2α>, a luteolytic factor, starts the luteolytic cascade within 5 minutes after intramascular injection in the cow, and PGF_<2α> stimulates luteolytic mediators within the corpus luteum. Addktionally, we showed the delay of luteolysis due to functional suppression of luteolytic mediators such as NOS, endothelin or angiotensin II.
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[Journal Article] Prostaglandin F_2_α increases endothelial nitric oxide synthase in the periphery of the bovine corpus luteum : the possible regulation of blood flow at an early stage of luteolysis2008
Author(s)
Shirasuna K, Watanabe S, Asahi T, Wijayagunawardane M. P. B, Sasahara K, Jiang C, Matsui M, Sasaki M, Shimizu T, Davis JS, Miyamoto A.
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Journal Title
Reproduction 135(4)
Pages: 527-539
Peer Reviewed
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[Presentation] Expression of steroidogenic factors and transcription factor, liver receptor homolog-1, in the bovine corpus luteum during the estrous cycle and early pregnancy2009
Author(s)
Nagai K, Shirasuna K, Beindorff N, Sasaki M, Shimizu T, Bollwein H, Miyamoto A.
Organizer
42^<nd> Annual Meeting, SSR,(David L..)Lawrence Convention Center
Place of Presentation
Pittsburgh, Pennsylvania
Year and Date
2009-07-20
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[Presentation] The expression of prostaglandin F2α receptor and its isoforms during the estrous cycle and luteolysis in the bovine corpus luteum2008
Author(s)
Akabane Y, Shirasuna K, Sasaki M, Matsui M, Berisha B, Schams D, Shimizu T, Miyamoto A.
Organizer
41^<th> Annual Meeting, SSR, Marriott Rivercenter
Place of Presentation
Kailua-Kona, Hawaii
Year and Date
2008-05-26
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[Presentation] The expression of EphB/ephrinB system in the bovine corpus luteum2007
Author(s)
Shirasuna K, Yamashita H, Ricken A, Borowski SB, Berisha B, Schams D, Shimizu T, Miyamoto A.
Organizer
40^<th> Annual Meeting, SSR, Marriott Rivercenter
Place of Presentation
San Antonio, Texas
Year and Date
2007-07-25
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[Presentation] The expression of transcription factors, DAX-1, SF-1 and LRH-1 for regulation steroidogenesis in the bovine corpus luteum2007
Author(s)
Nagai K, Sasahara K, Matsui M, Akemi Y, Berisha B, Schams D, Shimizu T, Miyamoto A.
Organizer
40^<th> Annual Meeting, SSR, Marriott Rivercenter
Place of Presentation
San Antonio, Texas
Year and Date
2007-07-24
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[Presentation] The expression and localization of apelin and its receptor APJ in the bovine corpus luteum2007
Author(s)
Miyamoto A, Sayama K, Shirasuna K, Asahi T, Shimizu T, Sasaki M, Matsui M, Akemi Y, Schams D, Berisha B.
Organizer
40^<th> Annual Meeting, SSR, Marriott Rivercenter
Place of Presentation
San Antonio, Texas
Year and Date
2007-07-24
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