2009 Fiscal Year Final Research Report
Development of reproductive biology by analysis of oocyte-producing male mouse strain
| Project/Area Number |
19380162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KON Yasuhiro Hokkaido University, 大学院・獣医学研究科, 教授 (10178402)
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| Co-Investigator(Kenkyū-buntansha) |
ENDOH Daiji 酪農学園大学, 獣医学部, 教授 (40168828)
SASAKI Nobuya 北海道大学, 大学院・獣医学研究科, 准教授 (20302614)
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| Project Period (FY) |
2007 – 2009
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| Keywords | マウス / 精巣 / 卵巣 / 始原生殖細胞 / 精巣内卵細胞 / 性決定因子 / セルトリ細胞 / 透明帯 |
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| Research Abstract |
The oocytes exist in seminiferous tubules of male MRL mice. As a result of the analysis, the testicular oocytes had several similar developmental dynamics, morphological characteristics, and functions to the ovarian oocytes. In the male MRL, the summaries are the following ; 1) the meiosis has already begun during embryogenesis, 2) sry mutation, male sex-determining factor was related with appearance of testicular oocytes, and 3) testicular oocytes have an ability for sperm acceptance. These results suggest an important finding that develop a new reproductive biology by the concept having an exchangeable availability of primordial germ cells from male to female.
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[Journal Article] Polymorphism in MRL and AKR mice Sry: a candidate gene for the appearance of testicular oocyte2008
Author(s)
Otsuka, S., Konno, A., Hashimoto, Y., Sasaki, N., Endoh, D., Kon, Y
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Journal Title
Jpn. J. Vet. Res 56(3)
Pages: 129-138
Peer Reviewed
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[Journal Article] Oocytes in newborn MRL mouse testes. Biol2008
Author(s)
Otsuka, S., Konno, A., Hashimoto, Y., Sasaki, N., Endoh, D., Kon, Y
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Journal Title
Biol. Reprod 79(1)
Pages: 9-16
Peer Reviewed
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[Journal Article] Altered balance of inhibitory and active Fc2008
Author(s)
Ichii, O., Konno, A., Sasaki, N., Endoh, D., Hashimoto, Y., Kon, Y
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Journal Title
Kidney Int 74(3)
Pages: 339-347
Peer Reviewed
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[Journal Article] Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ2008
Author(s)
Ichii, O. Konno, A., Sasaki, N., Endoh, D., Hashimoto, Y., Kon, Y
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Journal Title
Histol. Histopathol 23
Pages: 411-422
Peer Reviewed
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