2009 Fiscal Year Final Research Report
Quantitative analysis of pain response in isolated spinal cord and cultured dorsal root ganglion cell
| Project/Area Number |
19380163
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO Shigeo Hokkaido University, 大学院・獣医学研究科, 教授 (40109509)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUGURO Ken-ichi 北海道大学, 大学院・獣医学研究科, 准教授 (40344494)
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| Project Period (FY) |
2007 – 2009
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| Keywords | バニロイド受容体 / TRPV1チャネル / 背根神経節細胞 / 新生仔ラット脊髄 / ヒスタミン / 5-ヒドロキシトリプタミン / アデノシン / 腸管神経叢細胞 |
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| Research Abstract |
We found that vanilloid receptor (TRPV1) channels, being key proteins for pain generation, were activated by mustard oil or methylsalicylate in addition to a vanilloid compound such as capsaicin and that the opening of the channels was controlled by extracellular Na^+ ions. It was demonstrated that histamine and 5-hydroxy- tryptamine, which were released at inflammation sites, augmented pain due to TRPV1 channel activation through respective receptors for these amines, and that adenosine release was associated with the analgesic action in response to hypercapnia.
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Research Products
(27 results)
