2009 Fiscal Year Final Research Report
Molecular dissection of the vector-parasite relationship using Aedes-Filaria transmission system
| Project/Area Number |
19380165
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
FUKUMOTO Shinya Obihiro University of Agriculture and Veterinary Medicine, 原虫病研究センター, 講師 (50376422)
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| Co-Investigator(Kenkyū-buntansha) |
KANUKA Hirotaka 帯広畜産大学, 原虫病研究センター, 教授 (50342770)
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| Project Period (FY) |
2007 – 2009
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| Keywords | イヌ / フィラリア / ヤブカ / 寄生虫 |
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| Research Abstract |
The host -parasite relationship in vector mosquito, Aedes, and Filaria parasite was analyzed. Our data indicated that the mosquito innate immune systems were not significantly affect filarial infection to mosquito vector. This result suggested the presence of completely different anti-pathogen system against filarial parasite compare to small pathogens such as protozoa, bacteria or virus. The molting related genes of filarial parasite were considered as have a key role for host transition. Especially, cut1 gene transcripts were specifically detected in host transition stage. This result indicated that cut1 could be a useful drug target for establishing novel filarial parasite infection controlling strategy.
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