2009 Fiscal Year Final Research Report
Impairment of memory and neurotoxic mechanism in male mice induced by exposure of domoic acid.
| Project/Area Number |
19380174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
TANEMURA Kentaro National Institute of Health Sciences, 安全性生物試験研究センター・毒性部, 主任研究官 (20332322)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 毒性学 |
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| Research Abstract |
To know the neurotoxic mechanism induced by domoic acid (DA ; amnesic shellfish poison), we administered DA to male mice by intraperitoneal injection. We found subacute impairment of contextual memory and delayed cued memory loss by using fear conditioning test. Although we never detect histopathological damages, i.e. neural death, neurofibrillary tangles, neural loss, we found the effects on synapse by immunohistochemical study in hippocampus of mice. Furthermore, we found the influences on axonal guidance signal pathway and synaptic function in hippocampus of mice by molecular analysis using percellome methods.
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[Journal Article] Electrical stimulation modulates fate determination of differentiating embryonic stem cells.2007
Author(s)
Yamada M, Tanemura K, Okada S, Iwanami A, Nakamura M, Mizuno H, Ozawa M, Ohyama-Goto R, Kitamura N, Kawan M, Tan-Takeuchi K, Ohtsuka C, Miyawa A, Takashima A, Ogawa M, Toyama Y, Okano H, Kondo T.
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Journal Title
Stem Cells. 25(3)
Pages: 562-570
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