2009 Fiscal Year Final Research Report
Functional genomics of protein phosphatases in yeast
| Project/Area Number |
19380193
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Osaka University |
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Principal Investigator |
HARASHIMA Satoshi Osaka University, 工学研究科, 教授 (70116086)
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Yoshinobu 大阪大学, 工学研究科, 准教授 (90161182)
SUGIYAMA Minetaka 大阪大学, 工学研究科, 助教 (80379130)
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| Project Period (FY) |
2007 – 2009
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| Keywords | プロテインホスファターゼ / 酵母 / リン酸化・脱リン酸化 / プロテインキナーゼ / 核局在 |
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| Research Abstract |
We have been engaged in a project to explore the function of all the protein phosphatases in S.cerevisiae. As a part of this project, we have investigated in this study the function of four protein phosphatases, Siw14, Yvh1 Ptp2 and Msg5. We have revealed that Siwl4 regulates localization and activity of transcriptional activator Gln3 and Yvh1 is involved in mRNA stability as well as rRNA processing. We have also clarified a mechanism by which Ptp2 and Msg5 are involved in calcium response in redundant manner.
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[Journal Article] Deciphering cellular functions of protein phosphatases by comparison of gene expression profiles in Saccharomyces cerevisiae.2010
Author(s)
Hirasaki M, Nakamura F, Yamagishi K, Numamoto M, Shimada Y, Uehashi K, Muta S, Sugiyama M, Kaneko Y, Kuhara S, Harashima S.
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Journal Title
J Biosci Bioeng 109(5)
Pages: 433-41
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