2009 Fiscal Year Final Research Report
Development and application of high-throughput screening method for drug-seeds discovery in Chinese traditional medicines
| Project/Area Number |
19390013
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
HAGINAKA Jun Mukogawa Women's University, 薬学部, 教授 (20164759)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 分子インプリントポリマー / 中国伝承薬 / 創薬シード / ハイスループットスクリーニング |
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| Research Abstract |
An antibody can specifically recognize an antigen. A molecularly imprinted polymer, which is a synthetic antibody (artificial antibody), can specifically recognize a target compound, too. In this study, artificial antibodies for matrine and oxymatrine have been prepared to extract matrine, oxymatrine and their structurally related compound(s) in Chinese traditional medicines (TCMs). Furthermore, an artificial antibody for curcumine has been prepared to extract curcumine and its structurally related compound(s) in TCMs. The obtained results indicate that these antibodies work very well for specific extraction of the target compounds in TCMs.
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