2009 Fiscal Year Final Research Report
Biological response modification based on multi-template and dramatype approaches.
| Project/Area Number |
19390028
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HASHIMOTO Yuichi The University of Tokyo, 分子細胞生物学研究所, 教授 (90164798)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Hisayoshi 東京大学, 分子細胞生物学研究所, 助教 (80225531)
NOGUCHI Tomomi 東京大学, 分子細胞生物学研究所, 技術職員 (20401284)
AOYAMA Hiroshi 東京大学, 分子細胞生物学研究所, 助教 (40374699)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 医薬分子機能学 / 生物応答調節剤創製法 / 生理活性物質 |
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| Research Abstract |
Two approaches, named multi-template approach (focusing on three dimensional structure of the scaffold and its receptor) and dramatype approach (focusing on conformational change, time-dependent presence, trafficking, and/or stability of the receptor), have been proposed for the methodology to create various categories of biologically active compounds, including nuclear receptor ligands and thalidomide-related derivatives. Some unique active compounds were made commercially available as reagents.
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