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2009 Fiscal Year Final Research Report

Mechanisms underlying circulation of selenium in Biosphere

Research Project

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Project/Area Number 19390033
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental pharmacy
Research InstitutionChiba University

Principal Investigator

OGRA Yasumitsu  Chiba University, 薬学部, 教授 (40292677)

Co-Investigator(Kenkyū-buntansha) YAWATA Ayako  昭和薬科大学, 薬学部, 助教 (00384636)
SUZUKI Noriyuki  千葉大学, 大学院・薬学研究院, 准教授 (10376379)
Research Collaborator ENCINAR Jorge ruiz  University of Oviedo (Spain), Lecturer
Project Period (FY) 2007 – 2009
Keywordsセレン / メタロミクス / スペシエーション / カラシナ / セレノ糖 / ICP-MS / 生物循環 / メタロイド
Research Abstract

Selenium (Se) shows ambivalent characteristics in animals and plants. It is an essential element in animals but becomes severely toxic when the amount ingested exceeds the required level. Meanwhile, Se is not essential in plants although some plants are Se hyperaccumulators. Thus, Se may be circulated in biosphere. In the study, we obtained the results for the mechanisms underlying the Se metabolism in animals and plants, the distinguish between Se and tellurium in animals and plants, the novel approach for metal/metalloid metabolism by the combination techniques of molecular biology, speciation and elemental imaging as shown below.

  • Research Products

    (42 results)

All 2010 2009 2008 2007 Other

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (13 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Comparison of selenohomolanthionine and selenomethionine in terms of selenium distribution and toxicity in rats by bolus administration.2010

    • Author(s)
      Y. Tsuji, T. Mikami, Y. Anan, Y. Ogra*
    • Journal Title

      Metallomics (in press)

    • Peer Reviewed
  • [Journal Article] Roles of COMMD1 in stability and recruitment of the copper-transporting ATPase in mouse hepatoma cell line.2010

    • Author(s)
      T. Miyayama, D. Hiraoka, F. Kawaji, E. Nakamura, N. Suzuki, Y. Ogra*
    • Journal Title

      Biochem. J. 429

      Pages: 53-61

    • Peer Reviewed
  • [Journal Article] Effect of glutathione depletion on removal of copper from LEC rat livers by tetrathiomolybdate.2010

    • Author(s)
      Y. Ogra*, T. Miyayama, Y. Anan
    • Journal Title

      J. Inorg. Biochem. (in press)

    • Peer Reviewed
  • [Journal Article] Distinct uptake of tellurate from selenate in a selenium accumulator, Indian mustard (Brassica juncea).2010

    • Author(s)
      Y. Ogra*, E. Okubo, M. Takahira
    • Journal Title

      Metallomics 2

      Pages: 328-333

    • Peer Reviewed
  • [Journal Article] Distribution and metabolism of four different dimethylated arsenicals in hamsters.2010

    • Author(s)
      H. Naranmandura*, K. Iwata, K.T. Suzuki, Y. Ogra
    • Journal Title

      Toxicol. Appl. Pharmacol. 245

      Pages: 67-75

    • Peer Reviewed
  • [Journal Article] Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells.2009

    • Author(s)
      H. Naranmandura, Y. Ogra, K. Iwata, J. Lee, K.T. Suzuki, M. Weinfeld, X.C. Le*
    • Journal Title

      Toxicol. Appl. Pharmacol. 238

      Pages: 133-140

    • Peer Reviewed
  • [Journal Article] Metabolism of tellurium, antimony, and germanium simultaneously administered to rats.2009

    • Author(s)
      A. Kobayashi, Y. Ogra*
    • Journal Title

      J. Toxicol. Sci. 34

      Pages: 295-303

    • Peer Reviewed
  • [Journal Article] Systemic distribution and speciation of diphenylarsinic acid fed to rats.2009

    • Author(s)
      H. Naranmandura*, N. Suzuki, J. Takano, MW. Tony, Y. Ogra, K.T. Suzuki, X.C. Le
    • Journal Title

      Toxicol. Appl. Pharmacol 237

      Pages: 214-220

    • Peer Reviewed
  • [Journal Article] Copper accumulation and compartmentalization in mouse fibroblast lacking metallothionein and copper chaperone2009

    • Author(s)
      T. Miyayama, K.T. Suzuki, Y. Ogra*
    • Journal Title

      Atox1. Toxicol. Appl. Pharmacol 237

      Pages: 205-213

    • Peer Reviewed
  • [Journal Article] Selenium metabolism in rats with long-term ingestion of Se-methylselenocysteine using enriched stable isotopes.2009

    • Author(s)
      Y. Tsuji, N. Suzuki, K.T. Suzuki, Y. Ogra*
    • Journal Title

      J. Toxicol. Sci. 34

      Pages: 191-200

    • Peer Reviewed
  • [Journal Article] Speciation of selenomethionine metabolites in wheat germ extract.2009

    • Author(s)
      Y. Ogra*, T. Kitaguchi, K. Ishiwata, N. Suzuki, T. Toida, K.T. Suzuki
    • Journal Title

      Metallomics 1

      Pages: 78-86

    • Peer Reviewed
  • [Journal Article] Toxicometallomics for research on toxicology of exotic metalloids based on speciation studies.2009

    • Author(s)
      Y. Ogra*
    • Journal Title

      Anal. Sci. 25

      Pages: 1189-1195

    • Peer Reviewed
  • [Journal Article] Selenometabolomics: Identification of selenometabolites and specification of their biological significance by complementary use of elemental and molecular mass spectrometry.2009

    • Author(s)
      Y. Ogra*, Y. Anan
    • Journal Title

      J. Anal. At. Spectrom. 24

      Pages: 1477-1488

    • Peer Reviewed
  • [Journal Article] 植物におけるセレン及びその同族元素の代謝機構2009

    • Author(s)
      小椋康光*
    • Journal Title

      Biomed. Res. Trace Elements 20

      Pages: 240-246

    • Peer Reviewed
  • [Journal Article] Integrated strategies for identification of selenometabolites in animal and plant samples.2008

    • Author(s)
      Y. Ogra*
    • Journal Title

      Anal. Bioanal. Chem. 390

      Pages: 1685-1689

    • Peer Reviewed
  • [Journal Article] Development of miniaturized HPLC-ICP-MS for speciation of bio-trace elements.2008

    • Author(s)
      Ogra*
    • Journal Title

      Biomed. Res. Trace Elements 19

      Pages: 34-42

    • Peer Reviewed
  • [Journal Article] Speciation of selenium in selenium-enriched seeds, buckwheat (Fagopyrum esculentum Moench) and quinoa (Chenopodium quinoa Willdenow).2008

    • Author(s)
      T. Kitaguchi, Y. Ogra*, Y. Iwashita, K.T. Suzuki
    • Journal Title

      Eur. Food Res. Technol 277

      Pages: 1455-1460

    • Peer Reviewed
  • [Journal Article] Comparison of distribution and metabolism between tellurium and selenium in rats.2008

    • Author(s)
      Y. Ogra*, R. Kobayashi, K. Ishiwata, K.T. Suzuki
    • Journal Title

      J. Inorg. Biochem 102

      Pages: 1507-1513

    • Peer Reviewed
  • [Journal Article] Narrow bore HPLC-ICP-MS for speciation of copper in mutant mouse neonates bearing a defect in Cu metabolism.2008

    • Author(s)
      T. Miyayama, Y. Ogra*, Y. Osima, K.T. Suzuki
    • Journal Title

      Anal. Bioanal. Chem 390

      Pages: 1799-1804

    • Peer Reviewed
  • [Journal Article] In vitro translation with [34S]-labeled methionine, selenomethionine and telluromethionine.2008

    • Author(s)
      Y. Ogra*, T. Kitaguchi, N. Suzuki, K.T. Suzuki
    • Journal Title

      Anal. Bioanal. Chem. 390

      Pages: 45-51

    • Peer Reviewed
  • [Journal Article] Enhancement of nuclear localization of metallothionein by nitric oxide.2008

    • Author(s)
      Y. Ogra*, S. Onishi, A. Kajiwara, A. Hara, K.T. Suzuki
    • Journal Title

      J. Health Sci. 54

      Pages: 339-342

    • Peer Reviewed
  • [Journal Article] Identification of selenohomolanthionine in selenium-enriched Japanese pungent radish.2007

    • Author(s)
      Y. Ogra*, T. Kitaguchi, K. Ishiwata, N. Suzuki, Y. Iwashita, K.T. Suzuki
    • Journal Title

      J. Anal. At. Spectrom 22

      Pages: 1390-1396

    • Peer Reviewed
  • [Journal Article] メタロミクスにおけるスペシエーション2007

    • Author(s)
      小椋康光*
    • Journal Title

      ぶんせき

      Pages: 391-397

    • Peer Reviewed
  • [Journal Article] Effects of chemical species of selenium on maternal transfer during pregnancy and lactation.

    • Author(s)
      Y. Anan, Y. Ogra*, L. Somekawa, K.T. Suzuki
    • Journal Title

      Life Sci. 84

      Pages: 888-893

    • Peer Reviewed
  • [Presentation] 銅代謝における銅制御因子のクロストークとメタロチオネインの役割2010

    • Author(s)
      小椋康光
    • Organizer
      第15回東海メタロチオネイン研究会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-03-13
  • [Presentation] 細胞内銅制御因子COMMD1の機能解析2009

    • Author(s)
      小椋康光
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      20091021-20091024
  • [Presentation] 銅代謝におけるメタロチオネインの役割2009

    • Author(s)
      小椋康光
    • Organizer
      メタロチオネインおよびメタルバイオサイエンス研究会2009
    • Place of Presentation
      東京
    • Year and Date
      20091016-20091017
  • [Presentation] 生体内金属の動きと形を捉える:ハイフネーテッドテクニックとスペシエーション2009

    • Author(s)
      小椋康光
    • Organizer
      第20回日本微量元素学会
    • Place of Presentation
      東京
    • Year and Date
      20090702-20090703
  • [Presentation] Distinction of metalloids in metabolic pathway of animals and plants.2009

    • Author(s)
      Y. Ogra
    • Organizer
      2nd International Symposium on Metallomics.
    • Place of Presentation
      Cincinnati, USA
    • Year and Date
      2009-06-10
  • [Presentation] 微少化スペシエーションによる金属結合タンパク質の分析2008

    • Author(s)
      小椋康光
    • Organizer
      第一回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      20081128-20081129
  • [Presentation] 植物におけるセレンの代謝機構2008

    • Author(s)
      小椋康光
    • Organizer
      第19回日本微量元素学会
    • Place of Presentation
      東京
    • Year and Date
      20080703-20080704
  • [Presentation] Current status of metallomics research in Japan.2008

    • Author(s)
      Y. Ogra
    • Organizer
      XI Reunion del Grupo Regional Andaluz de la Sociedad Espanola de Quimica Analitica (XIth Conference of Analytical Chemical Society of Southern Spain)
    • Place of Presentation
      Huelva, Spain
    • Year and Date
      20080612-20080613
  • [Presentation] メタロミクスにおけるナノスペシエーション2008

    • Author(s)
      小椋康光
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      20080326-20080328
  • [Presentation] セレノメタボロミクスにおけるICP-MSとESI-MS/MS2008

    • Author(s)
      小椋康光
    • Organizer
      プラズマ分光分析研究会第74回講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-11
  • [Presentation] Distribution and metabolism of tellurium in rats ingested with sodium tellurite.2007

    • Author(s)
      Y. Ogra, R. Kobayashi, K. Ishiwata, K.T. Suzuki
    • Organizer
      VIIIth Conference of The International Society for Trace Element Research in Human
    • Place of Presentation
      Crete, Greece
    • Year and Date
      20071021-20071026
  • [Presentation] Speciation of selenium and identification of selenolanthionine in selenium-enriched Japanese pungent radish.2007

    • Author(s)
      Y. Ogra, T. Kitaguchi, K. Ishiwata, N. Suzuki, Y. Iwashita, K.T. Suzuki
    • Organizer
      Colloquium Spectroscopicum Internationale XXXV
    • Place of Presentation
      Xiamen, China
    • Year and Date
      20070923-20070927
  • [Presentation] 生体微量元素の微少化スペシエーション法の開発2007

    • Author(s)
      小椋康光
    • Organizer
      第18回日本微量元素学会
    • Place of Presentation
      福井
    • Year and Date
      20070705-20070706
  • [Book] セレンおよびテルル、レアメタル便覧(足立吟也ら)2010

    • Author(s)
      小椋康光
    • Publisher
      丸善(印刷中)
  • [Book] ICP/質量分析法、衛生試験法・注解20102010

    • Author(s)
      小椋康光
    • Publisher
      金原出版
  • [Remarks]

    • URL

      http://www.shoyaku.ac.jp/laboratory/eisei.html

  • [Patent(Industrial Property Rights)] テルルを含む土壌等からテルルを回収する方法2009

    • Inventor(s)
      小椋康光, 寺田麻里
    • Industrial Property Rights Holder
      国立大学法人千葉大
    • Industrial Property Number
      特願2009-005528号
    • Filing Date
      2009-01-14
  • [Patent(Industrial Property Rights)] セレン含有化合物並びにこれを含有する植物及び栄養剤2008

    • Inventor(s)
      Y. Ogra, Y. Iwashita, T. Kitaguchi, N. Suzuki, K.T. Suzuki
    • Industrial Property Rights Holder
      国立大学法人千葉大学
    • Industrial Property Number
      PCT/JP2008/056675
    • Filing Date
      2008-04-03

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Published: 2011-06-18   Modified: 2016-04-21  

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