2010 Fiscal Year Final Research Report
Unique response of hippocampal zinc in recognition and stress and prevention of stress-induced neuropsychological diseases
| Project/Area Number |
19390035
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental pharmacy
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
武田 厚司 University of Shizuoka, 薬学部, 准教授 (90145714)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 亜鉛 / 海馬 / 学習 / 記憶 / シナプス可塑性 / 長期増強 / ストレス / 精神障害 |
|---|
| Research Abstract |
Long-term potentiation (LTP) is known as a cellular mechanism of memory formation. In the hippocampus, Zn^<2+> attenuates mossy fiber LTP, while potentiated CA1 LTP. On the other hand, the stressful environment changes synaptic plasticity and memory formation. When rats were subjected to acute stress, zinc homeostasis in the extracellular compartment was significantly changed in the hippocampus. This change may attenuate LTP in the hippocampus. The present study suggests that Zn^<2+> signaling modulates LTP in the hippocampus.
|
Research Products
(35 results)
