2009 Fiscal Year Final Research Report
Alternative mechanisms of gene regulation for pharmacokinetics related genes
| Project/Area Number |
19390044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
HIGUCHI Shun Kyushu University, 大学院・薬学研究院, 教授 (40218699)
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| Co-Investigator(Kenkyū-buntansha) |
IEIRI Ichiro 九州大学, 大学院・薬学研究院, 准教授 (60253473)
HIROTA Takeshi 九州大学, 大学院・薬学研究院, 助教 (80423573)
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| Project Period (FY) |
2007 – 2009
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| Keywords | コピーナンバー多型 / miRNA / インプリンティング |
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| Research Abstract |
In this study, we focused on copy number variation, microRNA and genome imprinting. Copy number was increased in human tumor tissues compared to normal counter parts. Dihydropyrimidine dehydrogenase was repressed by some miRNAs. Inter-individual difference in human organic cation transporter was responsible for loss of imprinting.
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