2009 Fiscal Year Final Research Report
Gene-environmental interaction in early morphogenesis of the brain and developmental anomalies due to its disturbance
| Project/Area Number |
19390050
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kyoto University |
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Principal Investigator |
SHIOTA Kohei Kyoto University, 大学院・医学研究科, 名誉教授 (80109529)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Makoto 京都大学, 医学研究科, 教授 (30232341)
TAKIGAWA Toshiya 京都大学, 医学研究科, 助教 (90263095)
YAMADA Shigehito 京都大学, 医学研究科, 准教授 (80432384)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脳 / 形態形成 / 遺伝子 / 環境要因 / 発生異常 |
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| Research Abstract |
Sonic hedgehog (Shh) is a ventralizing factor in the developing brain. In this study, we showed that Shh is involved in the formation and patterning of the cerebral cortex and the morphogenesis of the ventral part of the eye. Ethanol exposure in early development can result in holoprosencephaly (HPE), which is a developmental anomaly of the forebrain. We used a mouse model of ethanol-induced HPE, and revealed that ethanol activates protein kinase C in the prechordal mesendoderm, thereby impairs the expression of Shh in the embryo and induces HPE malformations.
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