2009 Fiscal Year Final Research Report
ANALYSES OF DYNAMIC CHANGES AND THE FUNCTION OF TISSUE PLASMINOGEN ACTIVATOR IN ANIMAL MODELS OF DOPAMINE-RELATED MENTAL DISORDERS
| Project/Area Number |
19390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMADA Kiyofumi Nagoya University, 医学部附属病院, 教授 (30303639)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Taku 名古屋大学, 医学部附属病院, 准教授 (10377426)
MIZOGUCHI Hiroyuki 名古屋大学, 環境医学研究所, 助教 (70402568)
TAKUMA Kazuhiro 大阪大学, 大学院・薬学研究科, 准教授 (90289025)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 組織プラスミノーゲン活性化因子 / プラスミン / ドーパミン / 薬物依存 / 覚せい剤精神病 / 認知症 |
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| Research Abstract |
In the present study we investigated whether tissue plasminogen activator (tPA)-plasmin system was involved in the pathophysiology/pathogenesis of dopamine-related neuropsychiatric disorders, by using animal models for the diseases. Our findings suggest that tPA-plasmin may play a role in the development of methamphetamine dependence as well as methamphetamine-induced psychosis. Furthermore, it is indicated that the activation of dopamine D1 receptors leads to an increase in extracellular tPA activity and the dopamine D1 receptor-tPA signaling may play a role in memory formation.
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[Journal Article] Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice : a possible involvement of a brain specific transcription factor Npas4.2010
Author(s)
Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T, Yamada K
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Journal Title
J.Neurochem 114
Pages: 1840-1851
Peer Reviewed
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[Journal Article] Matrix metalloprotease-9 inhibition improves amyloid.-mediated cognitive impairment and neurotoxicity in mice.2009
Author(s)
Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa K, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T, Yamada K
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Journal Title
J.Pharmacol.Exp.Ther. 331
Pages: 14-22
Peer Reviewed
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[Journal Article] Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood.2009
Author(s)
Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda N, Nitta A, Nabeshima T, Yoneda Y, Yamada K
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Journal Title
Neurosci.Res. 64
Pages: 297-305
Peer Reviewed
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[Journal Article] Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice.2008
Author(s)
Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T, Yamada K
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Journal Title
J.Neurochem. 105
Pages: 921-932
Peer Reviewed
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[Journal Article] Activation of post-synaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling.2007
Author(s)
Ito M, Nagai T, Mizoguchi H, Sato K, Hayase M, Otsuka N, Fukakusa A, Kumagai N, Kim H-C, Nabeshima T, Takuma K, Yamada K
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Journal Title
J.Neurochem. 103
Pages: 2589-2596
Peer Reviewed
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[Journal Article] Ginkgo biloba extract EGb761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats.2007
Author(s)
Takuma K, Hoshina, Y, Arai S, Himeno Y, Matsuo, A, Funatsu Y, Kitahara Y, Ibi, D, Hayase M, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M, Yamada K
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Journal Title
Neuroscience 149
Pages: 256-262
Peer Reviewed
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