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2008 Fiscal Year Final Research Report

Analysis of regulatory mechanisms for cell migration and cell polarity by Wnt5a and Ror2 receptor tyrosine kinase

Research Project

  • PDF
Project/Area Number 19390076
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionKobe University

Principal Investigator

MINAMI Yasuhiro  Kobe University, 大学院・医学研究科, 教授 (70229772)

Co-Investigator(Kenkyū-buntansha) 依田 成玄  神戸大学, 大学院・医学系研究科, 助教 (70335454)
西田 満  神戸大学, 大学院・医学研究科, 准教授 (30379359)
寒川 延子  神戸大学, 大学院・医学系研究科, COE研究員 (30432579)
Project Period (FY) 2007 – 2008
KeywordsRor2受容体キナーゼ / Wnt5a / 細胞移動 / 細胞極性 / 細胞骨格
Research Abstract

ヒトをはじめとする多細胞生物の形態形成過程において、複雑かつ精緻に制御された細胞移動・細胞極性が重要な役割を担っている。我々はRor2受容体チロシンキナーゼが、形態形成において重要な役割を担う分泌蛋白質Wnt5aの受容体として機能することを明らかにしていたが、本研究ではWnt5a/Ror2による細胞移動・細胞極性を調節する細胞内情報伝達機構の解析を行うとともに、この情報伝達機構の異常とがん等の病態との関連の解析を行った。

  • Research Products

    (11 results)

All 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd22008

    • Author(s)
      Li, C., Chen, H., Hu, L., Xing, Y., Sasaki, T., Villosis, M. F., Li, J., Nishita, M., Minami, Y., and Minoo, P.
    • Journal Title

      BMC Mol. Biol 9

      Pages: 11-21

    • Peer Reviewed
  • [Journal Article] Cthrcl selectively activates planar cell polarity pathway of Wnt signaling by stabilizing Wnt-receptor complex2008

    • Author(s)
      Yamamoto, S., Nishimura, O., Misaki, K., Nishita, M., Minami, Y., Yonemura, S., Tarui, H., and Sasaki, H.
    • Journal Title

      Dev. Cell 15

      Pages: 23-36

    • Peer Reviewed
  • [Journal Article] Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A2008

    • Author(s)
      Nomachi, A., Nishita, M., Inaba, D., Enomoto, M., Hamasaki, M., and Minami, Y.
    • Journal Title

      J. Biol. Chem 283

      Pages: 27973-27981

    • Peer Reviewed
  • [Journal Article] Wnt5a regulates directional cell migration and cell proliferation via the Ror2-mediated noncanonical pathway in mammalian palate development2008

    • Author(s)
      He, F., Xiong, W., Yu, X., Espinoza, R., Liu, C., Nishita, M., Yamada, G., Minami, Y., and Chen, Y.
    • Journal Title

      Development 135

      Pages: 3871-3879

    • Peer Reviewed
  • [Journal Article] Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror22007

    • Author(s)
      Yamamoto, H., Yoo S-K., Nishita, M., Kikuchi, A., and Minami, Y.
    • Journal Title

      Genes Cells 12

      Pages: 1215-1223

    • Peer Reviewed
  • [Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation2007

    • Author(s)
      Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Kobayashi, S., Igarashi, M., Youn, M-Y., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K., and Kato, S.
    • Journal Title

      Nat. Cell Biol 9

      Pages: 1273-1285

    • Peer Reviewed
  • [Presentation] Wnt5a/Ror2シグナルによる細胞運動制御2008

    • Author(s)
      西田満、南康博
    • Organizer
      日本分子生物学会年会・日本生化学学会大会合同大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      20081209-12
  • [Presentation] Ror2 regulates cytoskeletal rearrangements to mediate Wnt5a-induced polarized cell migration2007

    • Author(s)
      西田満、南康博
    • Organizer
      日本分子生物学会年会・日本生化学学会大会合同大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20071211-15
  • [Book] 受容体型チロシンキナーゼRor2によるWntシグナルの制御 : 実験医学、26巻15号(増刊)2008

    • Author(s)
      西田満、南康博
    • Total Pages
      68-72
  • [Book] イラストレイテッド生化学原著4版Lippincott's Illustrated Reviews : Biochemistry 4th ed2008

    • Author(s)
      西田満、依田成玄、南康博(石崎泰樹、丸山敬 監訳)
    • Total Pages
      619
    • Publisher
      丸善(株)出版
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/medzoo/

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Published: 2010-06-10   Modified: 2016-04-21  

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