2009 Fiscal Year Final Research Report
Post-translational ,protein modification induced with reactive species in metabolic syndrome
| Project/Area Number |
19390090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
ADACHI Takeshi Keio University, 医学部, 講師 (50231931)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Michiko 慶應義塾大学, 医学部, 助教 (60445450)
IZUMI Yotaroy 慶應義塾大学, 医学部, 助教 (90245506)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 分子病態学 / メタボリック・シンドローム / プロテオミクス / インスリン / 血管内皮細胞 |
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| Research Abstract |
Metabolic syndrome is a complex diseases, which is closely associated with insulin resistance. In this study, we characterized aorta from Zucker rat, a typical animal model of MS. In aorta from MS, we found following results, 1) Hypo-vasoconstriction induced by iNOS, 2) A decrease in thiol-antioxidants, Changes in arginine, methionine metabolisms (including a decrease in SAM level, a methyl donor) 3) Decreases in the methyl-arginine modifications on vascular proteins. Moreover, we found the involvement of reactive oxygen/nitrogen species and gas molecules with insulin signal in cultured endothelial cells.
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[Journal Article] Long-term Carperitide Treatment Attenuates Left Ventricular Remodeling in Rats With Heart Failure After Autoimmune Myocarditis.2009
Author(s)
Tanaka K, Ito M, Kodama M, Hoyano M, Kimura S, Mitsuma W, Hirono S, Adachi T, Watanabe K, Nakazawa M, Aizawa Y
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Journal Title
J Cardiovasc Pharmacol 54(3)
Pages: 232-239
Peer Reviewed
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