2010 Fiscal Year Final Research Report
A Integrated Study of Pathological Significance of Cytosine Methylation of Non-CpG Island
| Project/Area Number |
19390100
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kobe University |
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Principal Investigator |
KITAZAWA Sohei Kobe University, 大学院・医学研究科, 客員教授 (90186239)
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| Co-Investigator(Kenkyū-buntansha) |
TAKENAKA Atsuhi 鳥取大, 医, 教授 (50368669)
KAJI Hiroshi 神戸大, 医, 特命准教授 (90346255)
KITAZAWA Riko 神戸大, 医, 特命准教授 (00273780)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 非CpCアイランド / メチル化 / 遺伝子プロモータ |
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| Research Abstract |
Cytosine methylation in CpG-island, located usually regulatory region of many genes, is well recognized as an inhibitory epigenetic regulator. On the other hand, biological significance of the cytosine methylation other than CpG-island is unclear. By focusing morphology-oriented microscopic dissection methods, we analyzed cytosine methylation status of the BAMBI gene promoter in bladder cancer and of the P16 in renal tumor of diabetic rats, and found that some of the cytosine methylation outside of the CpG-island contributes to the tumor development and progression.
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[Journal Article] Depressed expression of Klotho and FGFR1 in hyperplastic parathyroid glands from uremic patients.2010
Author(s)
Komaba H, Goto S, Fujii H, Hamada Y, Kobayashi A, Shibuya K, Tominaga Y, Otsuki N, Nibu K, Kitazawa R, Fukagawa M.
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Journal Title
Kidney Int 77
Pages: 232-238
Peer Reviewed
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[Journal Article] FSP27 Contributes to Efficient Energy Storage in Murine White Adipocytes by Promoting the Formation of Unilocular Lipid Droplets2008
Author(s)
Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, Inoue K, Kitazawa R, Kitazawa S, Matsuki Y, Hiramatsu R, Masubuchi S, Omachi A, Kimura K, Saito M, Amo T, Ohta S, Yamaguchi T, Osumi T, Cheng J, Fujimoto T, Nakao H, Nakao K, Aiba A, Okamura H, Fushiki T, Kasuga M
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Journal Title
J Clin Invest 118
Pages: 2808-2821
Peer Reviewed
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[Journal Article] Hepatic failure and enhanced oxidative stress in mitochondrial diabetes2008
Author(s)
Takahashi Y, Iida K, Takeno R, Kitazawa R, Kitazawa S, Kitamura H, Fujioka Y, Yamada H, Kanda F, Ohta S, Nishimaki K, Fujimoto M, Kondo T, Iguchi G, Takahashi K, Kaji H, Okimura Y, Chihara K
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Journal Title
Endocr J 55
Pages: 509-514
Peer Reviewed
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[Journal Article] Parathyroid hormone-responsive Smad3-related factor, Tmem119, promotes osteoblast differentiation and interacts with the bone morphogenetic protein-Runx2 pathway.
Author(s)
Hisa I, Inoue Y, Hendy GN, Canaff L, Kitazawa R, Kitazawa S, Komori T, Sugimoto T, Seino S, Kaji H
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Journal Title
Peer Reviewed
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