2008 Fiscal Year Final Research Report
Role of stress-inducible NKG2D ligands in disease
| Project/Area Number |
19390107
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KASAHARA Masanori Hokkaido University, 大学院・医学研究科, 教授 (30241318)
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| Co-Investigator(Kenkyū-buntansha) |
TOMARU Utano 北海道大学, 大学院・医学研究科, 講師 (20360901)
FUGO Kazunori 北海道大学, 大学院・医学研究科, 助教 (20431306)
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| Project Period (FY) |
2007 – 2008
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| Keywords | NKG2D / ナチュラルキラー細胞 / 活性化リガンド |
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| Research Abstract |
NKG2Dリガンドはがん化やウイルス感染に伴って、細胞表面に発現される主要組織適合遺伝子複合体クラスI様分子であり、免疫系に異常細胞の存在を知らせる危険信号の働きをしている。本研究では、我々が同定した2個の新規リガンドを中心として、NKG2Dリガンドの構造、機能、病態における役割を解析した
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Research Products
(22 results)
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[Journal Article] Exclusive expression of proteasome subunit β5t in the human thymic cortex2009
Author(s)
Tomaru, U., Ishizu, A., Murata, S., Miyatake, Y., Suzuki, S., Takahashi, S., Kazamaki, T., Ohara, J., Baba, T., Iwasaki, S., Fugo, K., Otsuka, N., Tanaka, K. and Kasahara, M.
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Journal Title
Blood doi : 10.1182/ blood-2008-11-187633
Peer Reviewed
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[Journal Article] Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D2008
Author(s)
Takada, A., Yoshida, S., Kajikawa, M., Miyatake, Y., Tomaru, U., Sakai, M., Chiba, H., Maenaka, K., Kohda, D., Fugo, K. and Kasahara, M.
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Journal Title
J. Immunol 180
Pages: 1678-1685
Peer Reviewed
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[Journal Article] and Ishizu, A.Rat CD4+/CD8+ macrophages kill tumor cells through an NKG2D- and granzyme/per for in-dependent2008
Author(s)
Baba, T., Iwasaki, S., Maruoka, T., Suzuki, A., Tomaru, U., Ikeda, H., Yoshiki, T., Kasahara, M
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Journal Title
mechanism. J. Immunol 180
Pages: 2999-3006
Peer Reviewed
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[Journal Article] Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. Nat2008
Author(s)
Yashiroda, H., Mizushima, T., Okamoto, K., Kameyama T., Hayashi, H., Kishimoto, T., Niwa, S., Kasahara, M., Kurimoto, E., Sakata, E., Takagi, K., Suzuki, A., Hirano, Y., Murata, S., Kato, K., Yamane, T. and Tanaka, K
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Journal Title
Struct. Mol. Biol 15
Pages: 228-236
Peer Reviewed
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[Journal Article] Structural diversity of the variable lymphocyte receptors2007
Author(s)
Kim, H. M., Oh, S. C., Lim, K. J., Kasamatsu, J., Heo, J. Y., Lee, H., Yoo, O. J., Kasahara, M, and Li, J.-O
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Journal Title
J. Biol. Chem 282
Pages: 6726-6732
Peer Reviewed
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[Journal Article] Enhanced production of p24 Gag protein in HIV-1-infected rat cells fused with uninfected human cells. Exp2007
Author(s)
Chen, J., Zhao, X., Lai, Y., Suzuki, A., Tomaru, U., Ishizu, A., Takada, A., Ikeda, H., Kasahara, M. and Yoshiki, T
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Journal Title
Mol. Pathol 83
Pages: 125-130
Peer Reviewed
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[Presentation] Role of mouse NKG2D ligand H60c in skin immunity2008
Author(s)
Yoshida, S., Fugo, K., Kasamatsu, J., Sarada, Y., Otsuka, N., and Kasahara, M.
Organizer
第38回日本免疫学会総会, 学術集会
Place of Presentation
京都
Year and Date
20081201-3
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[Presentation] The NKG2D ligand family of the mouse : A "danger signal" alerting the immune system. Regulation in Innate Immunity : From Recognition Molecules to Antimicrobial Peptides (Organizers : Ayabe, T., Kawano, K. and Matsushima, N2008
Author(s)
Kasahara, M., Yoshida, S., Kajikawa, M., Sarada, Y., Kasamatsu, J., Otsuka, N. and Fugo, K.
Organizer
October
Place of Presentation
Sapporo
Year and Date
20081028-29
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[Presentation] Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D2007
Author(s)
Fugo, K., Yoshida, S., Takada, A., Kajikawa, M., Miyatake, Y., Tomaru, U., Chiba, H., Maenaka, K., Kohda, D. and Kasahara, M.
Organizer
第37回日本免疫学会総会, 学術集会
Place of Presentation
東京
Year and Date
20071120-22
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