2008 Fiscal Year Final Research Report
Platelet function and dynamics in various phases of inflammation
| Project/Area Number |
19390108
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
ONO Masao Tohoku University, 大学院・医学系研究科, 教授 (20302218)
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Yasuo 東北大学, 大学院・歯学系研究科, 非常勤講師 (50005039)
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| Co-Investigator(Renkei-kenkyūsha) |
NOSE Masato 愛媛大学, 医学部, 教授 (70030913)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 血小板 / 炎症 / 自己免疫病 / 動物実験 |
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| Research Abstract |
血小板機能不全マウスを実験に利用して、様々なショック誘導や病態維持における血小板の機能を調べた。その結果、IgE依存性アレルギーショックからの回復機能、エンドトキシンショックに対する促進効果、アドレナリンショックに対する促進効果が初めて明らかとなった。今後は各ショック関連の血小板由来因子、作用を明らかにし、血小板を標的とした新たなショック治療に繋げていく
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Research Products
(32 results)
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[Journal Article] Co-inhibitory roles for glucocorticoid- induced TNF receptor in CD1d- dependent natural killer T cells2008
Author(s)
Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N
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Journal Title
Eur J Immunol 38
Pages: 2229-2240
Peer Reviewed
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[Journal Article] Fatty acid-binding protein regulates LPS-induced TNF-alpha production in mast cells2008
Author(s)
Yamamoto N, Kaneko I, Motohashi K, Sakagami H, Adachi Y, Tokuda N, Sawada T, Furukawa H, Ueyama Y, Fukunaga K, Ono M, Kondo H, Owada Y
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Journal Title
Prostaglandins Leukot Essent Fatty Acids 79
Pages: 21-26
Peer Reviewed
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[Journal Article] Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration2008
Author(s)
Tamai K, Toyoshima M, Tanaka N, Yamamoto N, Owada Y, Kiyonari H, Murata K, Ueno Y, Ono M, Shimosegawa T, Yaegashi N, Watanabe M, Sugamura K
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Journal Title
Am J Pathol 173
Pages: 1806-1817
Peer Reviewed
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