2009 Fiscal Year Final Research Report
Mechanisms of tolerance induction by apoptotic cell phagocytosis
| Project/Area Number |
19390117
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TANAKA Masato The Institute of Physical and Chemical Research, 自然免疫研究チーム, チームリーダー (00294059)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Kazuhiro 独立行政法人理化学研究所, 自然免疫研究チーム, 研究員 (90391929)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAKE Yasunobu 独立行政法人理化学研究所, 自然免疫研究チーム, 研究員 (10392143)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 死細胞 / 貪食 / 食細胞 / マクロファージ / 樹状細胞 / 免疫寛容 / 辺縁帯 |
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| Research Abstract |
The intravenous injection of apoptotic cells can induce cell associated antigen-specific immunosuppression or tolerance. This mechanism of tolerance induction requires the contributions of two populations of cells in the splenic marginal zone, macrophages that rapidly clear corpse in the blood flow, and CD8・^+, CD103^+ DCs that selectively phagocytose dead cell and subsequently present dead cell-associated antigen.
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