2008 Fiscal Year Final Research Report
Proteomic study on the mechanism underlying mucosal distruction by Helicobacter pylori CagA
| Project/Area Number |
19390122
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
HATAKEYAMA Masanori Hokkaido University, 遺伝子病制御研究所, 教授 (40189551)
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| Project Period (FY) |
2007 – 2008
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| Keywords | 感染症 / 細菌 / シナルグ伝達 / プロテオーム |
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| Research Abstract |
ヘリコバクター・ピロリ菌は、自らが保有するIV型分泌機構を介して病原タンパク質CagAを宿主胃上皮細胞内に注入する。本研究を通して、胃上皮細胞内に侵入したピロリ菌CagAの細胞内標的分子分子として、上皮細胞極性制御のマスターレギュレーターであるPAR1ファミリーキナーゼが同定された。CagAはPAR1と結合しそのキナーゼ活性を抑制する結果、胃粘膜を構成する極性化上皮細胞層の崩壊を引き起こし、胃粘膜を傷害することが明らかとなった。
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[Journal Article] Structural and functional diversity in the PAR1b/MARK2-binding region of Helicobacter pylori CagA.2008
Author(s)
Lu, H., Saito, Y., Umeda, M., Murata-Kamiya, N., Zhang, H., Higashi, H. and Hatakeyama, M.
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Journal Title
Cancer Science 99
Pages: 2004-2011
Peer Reviewed
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[Journal Article] Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.2008
Author(s)
Nakajima, J., Ishikawa, S., Hamada, J., Yanagihara, M., Koike, T. and Hatakeyama, M., Yanagihara, M., Koike, T. and Hatakeyama, M.
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Journal Title
Biochem. Biophys. Res. Commun. 370
Pages: 189-194
Peer Reviewed
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[Journal Article] Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.2008
Author(s)
Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., Yamada, G., Azuma, T. and Hatakeyama, M.
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Journal Title
Proc. Natl. Acad. Sci. USA 105
Pages: 1003-1008
Peer Reviewed
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[Journal Article] Isolation of a distinct class of gain-of-function SHP-2 muntants with oncogenic RAS-like transforming activity from solid tumors.2008
Author(s)
Miyamoto, D., Miyamoto, M., Takahashi, A., Yomogita, Y., Higashi, H., Kondo, S. and Hatakeyama, M.
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Journal Title
Oncogene 27
Pages: 3508-3515
Peer Reviewed
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[Journal Article] Deregulation of ss-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence.2008
Author(s)
Kurashima, Y., Murata-Kamiya, N., Kikuchi,K., Higashi, H., Azuma, T., Kondo, S. and Hatakeyama, M.
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Journal Title
International Journal of Cancer 122
Pages: 823-831
Peer Reviewed
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[Journal Article] Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.2007
Author(s)
Saadat, I., Higashi, H., Obuse, C., Umeda, M., Murata-Kamiya, N., Saito, Y., Lu, H., Ohnishi, N., Azuma, T., Suzuki, A., Ohno, S. and Hatakeyama, M.
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Journal Title
Nature 447
Pages: 330-333
Peer Reviewed
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[Journal Article] Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.2007
Author(s)
Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek, R.M., Jr., Azuma, T. and Hatakeyama, M.
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Journal Title
Oncogene 26
Pages: 4617-4626
Peer Reviewed
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