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2008 Fiscal Year Final Research Report

ACTIVATION MECHANISM OF INNATE IMMUNE SYSTEM BY INTERLEUKIN-15

Research Project

  • PDF
Project/Area Number 19390136
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionAkita University

Principal Investigator

OHTEKI Toshiaki  Akita University, 医学部, 教授 (50233200)

Project Period (FY) 2007 – 2008
Keywords自然免疫 / 樹状細胞 / サイトカイン / Toll様受容体 / 免疫賦活
Research Abstract

インターロイキン15(IL-15)は自然免疫系の活性化に重要なサイトカインである。樹状細胞(DC)やマクロファージなどの抗原提示細胞、さらには上皮細胞などがIL-15を生産するが、その分子機構には不明な点が多い。我々は、代表的なToll様受容体リガンドであるCpGでDCを刺激すると、IL-12が生産され、IL-12依存性に転写因子IRF3が活性化して、IRF3依存性にIL-15の生産が誘導される経路を明らかにした。

  • Research Products

    (23 results)

All 2009 2008 2007 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (11 results) Book (2 results) Remarks (1 results)

  • [Journal Article] IRF-2 protects quiescent HSCs from type-I interferondependent exhaustion2009

    • Author(s)
      Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T., and Ohteki, T.
    • Journal Title

      Nat. Med. (in press)

    • Peer Reviewed
  • [Journal Article] MHC-matched corneal allograft rejection in an IFN-γ/IL-17- independent manner in C57BL/6 mice. Invest2009

    • Author(s)
      Yamada, J., Hamuro, J., Fukushima, A., Ohteki, T., Terai, K., Iwakura, Y., Yagita, H., and Kinoshita, S.
    • Journal Title

      Ophth. Vis. Sci. 50

      Pages: 2139-2146

    • Peer Reviewed
  • [Journal Article] IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease2009

    • Author(s)
      Miyagawa, F., Tagaya, Y., Kim, B.S., Patel, H.J., Ishida, K., Ohteki Waldmann, T.A., and Katz, S.I.
    • Journal Title

      J. Immunol. 181

      Pages: 1109-1119

    • Peer Reviewed
  • [Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages2008

    • Author(s)
      Kuroda, S., Nishio, M., Sasaki, T., Horie, Y., Kawahara, K., Sasaki, M., Natsui, M., Matozaki, T., Tezuka, H., Ohteki, T., Forster, I., Mak, T.W., Nakano, T., and Suzuki, A.
    • Journal Title

      Eur. J. Immunol. 38

      Pages: 1331-1340

    • Peer Reviewed
  • [Journal Article] Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4^+ self-reactive T cells2008

    • Author(s)
      Terme, M., Chaput, N., Combadiere, B., Ma, A., Ohteki, T., and Zitvogel, L
    • Journal Title

      J. Immunol. 180

      Pages: 4679-4686

    • Peer Reviewed
  • [Journal Article] Identification of clonogenic common Flt3^+MCSFR^+plasmacytoid and dendritic cell progenitors in mouse bone marrow2007

    • Author(s)
      Onai, N., Obata-Onai, A., Schmid, M.A., Ohteki, T., Jarrossay, D., and Manz, M.G.
    • Journal Title

      Nat. Immunol. 8

      Pages: 1207-1216

    • Peer Reviewed
  • [Journal Article] production by naturally occurring TNF/iNOSproducing dendritic cells2007

    • Author(s)
      Tezuka, H., Abe, Y., Iwata, M, Takeuchi, H., Ishikawa, H., Matsushita, M., Shiohara, T., Akira, S., and Ohteki, T.
    • Journal Title

      Nature 448

      Pages: 929-933

    • Peer Reviewed
  • [Journal Article] The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells2007

    • Author(s)
      Kishimoto, H.,*Ohteki, T.*(*equal contribution)Yajima, N., Kawahara, K., Natsui, M., Kawarasaki, S., Hamada, K., Horie, Y., Kubo, Y., Arase, S., Taniguchi, M., Vanhaesebroeck, B., Mak, T.W., Nakano, N., Koyasu, S., Sasaki, T., and Suzuki, A.
    • Journal Title

      Blood 109

      Pages: 3316-3324

    • Peer Reviewed
  • [Journal Article] The dynamics of dendritic cellmediated innate immune regulation2007

    • Author(s)
      Ohteki, T.
    • Journal Title

      Allergol. Int 56

      Pages: 209-214

    • Peer Reviewed
  • [Presentation] Proliferation and exhausion of HSCs by type-1 interferon2009

    • Author(s)
      Ohteki, T.
    • Organizer
      第8回日本再生医療学会総会, シンポジウムStem Cell Niche
    • Place of Presentation
      東京
    • Year and Date
      20090305-06
  • [Presentation] The role of hematopoietic cytokine in dendritic cell subsets development2008

    • Author(s)
      Onai, N.
    • Organizer
      第38日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20081201-03
  • [Presentation] IRF-2 protects haematopoietic stem cells from type-I interferon-dependent replicative exhaustion2008

    • Author(s)
      Sato, T.
    • Organizer
      第38日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      20081201-03
  • [Presentation] Molecular mechanism of IL-15 production from DC upon CpG stimulation in vivo2008

    • Author(s)
      Kuwajima, S.
    • Organizer
      第38日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      20081201-03
  • [Presentation] Molecular mechanism of DC production of IL-15 upon CpG stimulation in vivo2008

    • Author(s)
      Fujioka, Y.
    • Organizer
      The 10th International Symposium on Dendritic Cells
    • Place of Presentation
      神戸
    • Year and Date
      20081001-05
  • [Presentation] Plasmacytoid dendritic cell-derived interferon-α regulates dendritic cell homeostasis2007

    • Author(s)
      Kuwajima, S.
    • Organizer
      第7回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路
    • Year and Date
      20070902-05
  • [Presentation] 形質細胞様樹状細胞の生産するIFN-αによる新規免疫制御機構2007

    • Author(s)
      樗木俊聡
    • Organizer
      第18回樹状細胞研究会
    • Place of Presentation
      淡路
    • Year and Date
      20070823-24
  • [Presentation] Plasmacytoid dendritic cell-derived interferon-a regulates dendritic cell homeostasis2007

    • Author(s)
      Ohteki, T.
    • Organizer
      International Symposium on Molecular Cell Biology of Macrophages 2007
    • Place of Presentation
      静岡
    • Year and Date
      20070614-15
  • [Presentation] 樹状細胞による免疫調節ダイナミズム研究2007

    • Author(s)
      樗木俊聡
    • Organizer
      第10回日本免疫学会賞受賞講演)第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
  • [Presentation] pDC-derived interferon-α downregulates TLR7-mediated immune responses through DC apoptosis2007

    • Author(s)
      Kuwajima, S.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
  • [Presentation] 樹状細胞による粘膜免疫調節機構2007

    • Author(s)
      樗木俊聡
    • Organizer
      第3回東北内分泌研究会総会(第15回日本内分泌学会東北地方会)
    • Place of Presentation
      秋田
    • Year and Date
      2007-10-13
  • [Book] 樹状細胞による免疫調節ダイナミズム,免疫応答と免疫病態の統合的分子理解(谷口維紹, 本一彦)2007

    • Author(s)
      樗木俊聡
    • Total Pages
      125-134
    • Publisher
      南山堂,東京
  • [Book] CpGによる樹状細胞活性化とIL-15 依存性クロストーク. Annual Review免疫2008(奥村康, 平野俊夫, 佐藤昇志)2007

    • Author(s)
      桑島精一、樗木俊聡
    • Total Pages
      138-145
    • Publisher
      中外医学社,東京
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~kisei/Default.html

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Published: 2010-06-10   Modified: 2016-04-21  

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