2009 Fiscal Year Final Research Report

A novel mechanism of resistance to methylmercury toxicity in central nerves systems

Research Project

Project/Area Number	19390159
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Hygiene
Research Institution	Tohoku University
Principal Investigator	NAKAI Kunihiko Tohoku University, 大学院・医学系研究科, 准教授 (00291336)
Co-Investigator(Kenkyū-buntansha)	SATOH Hiroshi 東北大学, 大学院・医学系研究科, 教授 (40125571) KUROKAWA Naoyuki 東北大学, 大学院・医学系研究科, 助教 (30431505)
Research Collaborator	YAGINUMA Kozue 東北大学, 大学院・医学系研究科, 大学院生 SHIMADA Miyuki 東北大学, 大学院・医学系研究科, 大学院生
Project Period (FY)	2007 – 2009
Keywords	環境保健
Research Abstract	A novel mechanism of resistance to methylmercury (MeHg) toxicity in central nerve system has been examined using mice exposed to MeHg prenatally. As a preliminary examination, acute and chronic gene expression after MeHg exposure has been examined, and revealed that the altered genes were related to the functional categories of development, inflammation, and cell death. The next examination had performed by the combined exposures during prenatal and adulthood periods, and gene expression profiling had been examined.