2010 Fiscal Year Final Research Report
Development of preventive therapy of no-se-induced hearing loss through clarifying its mechanism
| Project/Area Number |
19390168
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Chubu University |
|---|
Principal Investigator |
KATO MASASHI Chubu University, 生命健康科学部, 教授 (10281073)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHGAMI Nobutaka 中部大学, 生命健康科学部, 講師 (80424919)
|
|---|
| Project Period (FY) |
2007 – 2010
|
| Keywords | 環境ストレス / 労働衛生学 / 難聴 / 色素細胞 / 分子標的療法 |
|---|
| Research Abstract |
We found that congenital syndromic hearing loss was induced by the loss of function of c-RET, a regulator of growth of neuron and melanocytes, in humans. We then showed that c-Ret-mediated congenital hearing loss was caused of degeneration of spiral ganglion neurons in inner ear in mice. We also examined whether c-Ret is correlated with age-related and noise-induced hearing loss. Moreover, we performed epidemiological study to investigate the correlation between noise and hearing loss in young adults.
|
Research Products
(26 results)
-
[Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice.2011
Author(s)
Ohgami N, Ida-Etoh M, SakashitaN, Sone M, Nakashima N, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M
-
Journal Title
Neurobiol Aging (in press)
Peer Reviewed
-
-
-
[Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease.2010
Author(s)
Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M
-
Journal Title
Proc Natl Acad Sci USA 107(29)
Pages: 13051-6
Peer Reviewed
-
[Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation.2010
Author(s)
Kato M, Takeda K, Hossain K, Thang D.Nguyen, Kaneko Y, Kumasaka M,Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y
-
Journal Title
J Cell Biochem 110
Pages: 399-407
Peer Reviewed
-
-
-
[Journal Article] Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.2009
Author(s)
Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F
-
Journal Title
Dev Cell 17(2)
Pages: 199-209
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
