2009 Fiscal Year Final Research Report
Studies on metal toxicology and transport using omics approaches
| Project/Area Number |
19390169
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hygiene
|
|---|
| Research Institution | Tokushima Bunri University |
|---|
Principal Investigator |
HIMENO Seiichiro Tokushima Bunri University, 薬学部, 教授 (20181117)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJISHIRO Hitomi 徳島文理大学, 薬学部, 助教 (10389182)
MIYATAKA Hideki 徳島文理大学, 薬学部, 助教 (50157658)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Keywords | オミクス / 重金属 / 毒性 / 遺伝子 / 環境 |
|---|
| Research Abstract |
The mechanisms of toxicity and transport of heavy metals remain unclear. To solve this problem, we applied OMICS strategy in which DNA microarray and other high-throughput techniques are utilized to analyze the whole profiles of changes in the expression of gene, protein, and metabolites. As a result, we identified a novel transport system for cadmium, novel indicator for renal cadmium toxicity, and responsive factors against arsenic toxicity.
|
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Androgen-dependent Gene Expression of Prostate-specific Antigen Is Enhanced Synergistically by Hypoxia in Human Prostate Cancer Cells: Cross-talk between the Androgen Receptor and Hypoxia-inducible Factor-1 Signaling.2007
Author(s)
Horii, K., Suzuki, Y., Kondo, Y., Akimoto, M., Nishimura, T., Yamabe, Y., Sakaue, M., Sano, T., Kitagawa, T., Himeno, S., Imura, N., Hara, S.
-
Journal Title
Mol. Cancer Res. 5(4)
Pages: 383-391
Peer Reviewed
-
[Journal Article] Induction of metallothionein by manganese is completely dependent on interleukin-6 production.2007
Author(s)
Kobayashi, K., Kuroda, J., Shibata, N., Hasegawa, T., Seko, Y., Satoh, M., Tohyama, C., Takano, H., Imura, N., Sakabe, K., Fujishiro, H., Himeno, S.
-
Journal Title
J. Pharmacol. Exp. Ther. 320(2)
Pages: 721-727
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
