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2009 Fiscal Year Final Research Report

Evaluation of effects of salt reduction on blood pressure and behavior with genetic polymorphism information

Research Project

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Project/Area Number 19390173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionKeio University (2008-2009)
Kyoto University (2007)

Principal Investigator

宮木 幸一  Keio University, 医療情報解析研究部, 室長 (20327498)

Co-Investigator(Kenkyū-buntansha) 村松 正明  東京医科歯科大学, 難治疾患研究所, 教授 (50230008)
Project Period (FY) 2007 – 2009
Keywords成人保健 / テイラーメイド予防
Research Abstract

We evaluated the effects of our salt reduction intervention developed by the behavioral theory on blood pressure and behavior with genetic polymorphism information. We assessed the interaction of salt intake and genetic polymorphisms selected by candidate gene approach and Genome Wide Association Studies in Japanese population. Risk allele score of our results showed significant linear association with blood pressure. Information of polymorphism which affects blood pressure and the responsiveness to the salt reduction was gained which will be useful for future tailor-made prevention of hypertension.

  • Research Products

    (19 results)

All 2010 2009 2008 2007 2006

All Journal Article (11 results) Presentation (8 results)

  • [Journal Article] CDKAL1 polymorphism is associated with elevated HbA1c levels and the prevalence of metabolic syndrome in Japanese men: Interaction with dietary energy intake.2010

    • Author(s)
      Miyaki K, Oo T, Song Y, Lwin H, Tomita Y, Hoshino H, Suzuki N, Muramatsu M
    • Journal Title

      Am J Epidemiol (in press)

  • [Journal Article] Genetic Polymorphisms in Homocysteine Metabolism and Response to Folate Intake. -A Comprehensive Strategy to Elucidate the Useful Genetic Information-2010

    • Author(s)
      Miyaki K.
    • Journal Title

      J Epidemiol (in press)

  • [Journal Article] CYP3A5 polymorphism and sensitivity of blood pressure to dietary salt in Japanese men.2010

    • Author(s)
      Zhang L, Miyaki K, Wang W, Muramatsu M
    • Journal Title

      J Hum Hypertens 24

      Pages: 345-50

  • [Journal Article] Association between a Polymorphism of Aminolevulinate Dehydrogenase (ALAD) Gene and Blood Lead Levels in Japanese Subjects.2009

    • Author(s)
      Miyaki K, Lwin H, Masaki K, Song Y, Takahashi Y, Muramatsu M, Nakayama T
    • Journal Title

      Int J Environ Res Public Health 6

      Pages: 999-1009

  • [Journal Article] Increasing the number of SNPs loci does not necessarily improve prediction power at least in the comparison of MTHFR SNP and haplotypes.2008

    • Author(s)
      Miyaki K, Takahashi Y, Song Y, Zhang L, Muramatsu M, Nakayama T
    • Journal Title

      J Epidemiol 18

      Pages: 243-50

  • [Journal Article] Influence of CYP11B2 Gene Polymorphism on the Prevalence of Hypertension and the Blood Pressure in Japanese Men: Interaction with Dietary Salt Intake.2008

    • Author(s)
      Song Y, Miyaki K, Araki J, Zhang L, Takahashi Y, Nakayama T, Muramatsu M
    • Journal Title

      J Nutrigenetics and Nutrigenomics 1

      Pages: 252-8

  • [Journal Article] Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G-->T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men.2008

    • Author(s)
      Zhang L, Miyaki K, Nakayama T, Muramatsu M
    • Journal Title

      Metabolism 57

      Pages: 502-5

  • [Journal Article] Association between vitamin D receptor gene haplotypes and chronic periodontitis among Japanese men.2007

    • Author(s)
      Naito M, Miyaki K, Naito T, Zhang L, Hoshi K, Hara A, Masaki K, Tohyama S, Muramatsu M, Hamajima N, Nakayama T
    • Journal Title

      Int J Med Sci 4

      Pages: 216-22

  • [Journal Article] The relation between nicotinamide N-methyltransferase gene polymorphism and plasma homocysteine concentration in healthy Japanese men.2007

    • Author(s)
      Zhang L, Miyaki K, Araki J, Nakayama T, Muramatsu M
    • Journal Title

      Thromb Res 121

      Pages: 55-8.

  • [Journal Article] The interaction between the IL6R genotype and dietary energy intake on abdominal obesity in Japanese men.2007

    • Author(s)
      Song Y, Miyaki K, Araki J, Zhang L, Omae K, Muramatsu M
    • Journal Title

      Metabolism 56

      Pages: 925-30

  • [Journal Article] Interaction of Angiotensin I converting enzyme I/D polymorphism and daily salt intake influences hypertension in Japanese men.2006

    • Author(s)
      Zhang L, Miyaki K, Araki J, Song Y, Kimura T, Omae K, Muramatsu M
    • Journal Title

      J Hypertens 29

      Pages: 751-58

  • [Presentation] Salt reduction intervention in workplace based on behavioral theories-Rationale and design of a randomized controlled trial-2010

    • Author(s)
      Koichi Miyaki, Htay Lwin, Saeko Fujii, Hirofumi Sakurazawa, Hidehiko Ando, Yixuan Song, Masaaki Muramatsu, Yoshimitsu Takahashi, Haruhiko Hoshino, NorihiroSuzuki, Takuro Shimb
    • Organizer
      The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
    • Place of Presentation
      Saitama, Japan
    • Year and Date
      20100108-20100110
  • [Presentation] The Evaluation of the Focused Health Checkup/Focused Health Consultation System Focusing on Metabolic Syndrome with Hypertension2010

    • Author(s)
      Htay Lwin, Koichi Miyaki, Saeko Fujii, Hirofumi Sakurazawa, Hidehiko Ando, Yixuan Song, Masaaki Muramatsu, Yoshimitsu Takahashi, Takeo Nakayama, Haruhiko Hoshino, Norihiro Suzuki, Takuro Shimbo
    • Organizer
      The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
    • Place of Presentation
      Saitama, Japan
    • Year and Date
      20100108-20100110
  • [Presentation] The Effect of CDKAL1 Polymorphism on Metabolic Phenotypes in an Occupational Cohort in Japan2010

    • Author(s)
      Shinobu Ikeda, Koichi Miyaki, Htay Lwin, Saeko Fujii, Hirofumi Sakurazawa, Hidehiko Ando, Yixuan Song, Masaaki Muramatsu, Yoshimitsu Takahashi, Haruhiko Hoshino, NorihiroSuzuki, Takuro Shimbo
    • Organizer
      The Joint Scientific Meeting of IEA Western Pacific Region and Japan Epidemiological Association
    • Place of Presentation
      Saitama, Japan
    • Year and Date
      20100108-20100110
  • [Presentation] HapMapデータベースにより構築したMTHFR遺伝子多型ハプロタイプ情報を用いたランダム化比較試験による葉酸投与時のホモシステイン低下量の差異の検討2008

    • Author(s)
      宮木幸一, 高橋由光, 宋毅シュアン, 張玲, 村松正明, 中山健夫
    • Organizer
      第18回日本疫学会学術総会
    • Place of Presentation
      順天堂大学
    • Year and Date
      20080125-20080126
  • [Presentation] 日本人男性におけるCYP11B2遺伝子多型と高血圧との関連性と塩分摂取量との相互作用宋毅シュアン2008

    • Author(s)
      宮木幸一, 荒木淳吾, 張玲, 高橋由光, 中山健夫, 村松正明
    • Organizer
      第18回日本疫学会学術総会
    • Place of Presentation
      順天堂大学
    • Year and Date
      20080125-20080126
  • [Presentation] 塩分感受性高血圧SNPs情報提供が高校生の減塩行動に及ぼす影響の評価--自記式質問票によるパイロット調査--2007

    • Author(s)
      宮木幸一, 友田茉莉, 西山深雪, 加納圭, 上田英未, 張玲, 加藤和人, 小杉眞司, 中山健夫
    • Organizer
      日本人類遺伝学会第52回大会
    • Place of Presentation
      京王プラザ、東京
    • Year and Date
      20070912-20070915
  • [Presentation] 日本人男性におけるNNMT遺伝子A/G多型とホモシステイン、葉酸、MTHFR遺伝子C677T多型との関連の検討2007

    • Author(s)
      張玲, 宮木幸一, 荒木淳吾, 中山健夫, 村松正明
    • Organizer
      第17回日本疫学会学術総会
    • Place of Presentation
      広島市南区民文化センター
    • Year and Date
      20070126-20070127
  • [Presentation] 日本人男性におけるProstacyclin Synthase遺伝子多型と高血圧との関連性宋毅シュアン2007

    • Author(s)
      宮木幸一, 荒木淳吾, 張玲, タンウー, 中山健夫, 村松正明
    • Organizer
      第17回日本疫学会学術総会
    • Place of Presentation
      広島市南区民文化センター
    • Year and Date
      20070126-20070127

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Published: 2011-06-18   Modified: 2016-04-21  

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