2009 Fiscal Year Final Research Report
Molecular mechanism in pathogenesis of arsenic intoxication-toward forensic molecular toxicological clarification-
| Project/Area Number |
19390187
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
KIMURA Akihiko Wakayama Medical University, 医学部, 准教授 (60136611)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Toshikazu 和歌山県立医科大学, 医学部, 教授 (70251923)
ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077)
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| Research Collaborator |
MUKAIDA Naofumi 金沢大学, がん研究所, 教授 (30182067)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 砒素中毒 / IL-6 / autophagy / Stat3 / ERK / 性差 / estrogen / 腎障害 |
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| Research Abstract |
We analyzed pathophysiological roles of inflammatory cytokine, IL-6, and female sex hormone, estrogen, in arsenite-induced renal injury by using mouse models. We found a crucial involvement of autophagic cell death of renal tubular epithelial cells in pathogenesis of arsenite-induced renal injury. We clarified that IL-6 played a protective role in pathogenesis of arsenite-induced renal injury by reduction of autophagy through suppression of ERK phosphorylation. We also found a gender difference in susceptibility to renal toxicity of arsenite, which was caused by an interference of IL-6/Stat3 signaling by estrogen.
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