2009 Fiscal Year Final Research Report
Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides
| Project/Area Number |
19390189
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUDO Shin Tohoku University, 大学院・医学系研究科, 教授 (80199249)
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| Co-Investigator(Kenkyū-buntansha) |
KANAZAWA Motoyori 東北大学, 大学院・医学系研究科, 講師 (70323003)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 脳腸相関 / 過敏性腸症候群 / corticotropin-releasing hormone (CRH) / 内臓感覚 / 消化管運動 / 脳画像 / CRH-R1受容体 / α-helical CRH |
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| Research Abstract |
It is important to clarify the precise mechanism of brain-gut interactions and pathogenesis of irritable bowel syndrome (IBS). We focused on the role of corticotropin-releasing hormone (CRH) in these phenomena. Administration of non-peptide CRH antagonist improved visceral hypersensitivity and flare-up of inflammation in the animal model of IBS after the experimental colitis. Administration of peptide CRH antagonist improved electrophysiological properties of the brain in patients with IBS. Further studies on brain-gut peptides in this issue are warranted.
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Research Products
(31 results)
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[Journal Article] Increased brain histamine H1 receptor binding in patients with anorexia nervosa.2009
Author(s)
Yoshizawa M, Tashiro M (Equally Contributing First Author), Fukudo S, Yanai K, Utsumi A, Kano M, Karahasi M, Endo Y, Morisita J, Sato Y, Adachi M, Itoh M, Hongo M
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Journal Title
Biol Psychiatry 65
Pages: 329-335
Peer Reviewed
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[Journal Article] Brain activation correlates with changes in heart rate and autonomic function during rectal distention.2009
Author(s)
Suzuki H, Watanabe S, Hamaguchi T, Mine H, Terui T, Kanazawa M, Oohisa N, Maruyama M, Yambe T, Itoh M, Fukudo S
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Journal Title
Psychosom Med 71
Pages: 619-626
Peer Reviewed
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[Journal Article] Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention.2009
Author(s)
Fukudo S, Kanazawa M, Mizuno T, Hamaguchi T, Kano M, Watanabe S, Sagami Y, Shoji T, Endo Y, Hongo M, Itoyama Y, Yanai K, Tashiro M, Aoki M
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Journal Title
Neuroimage 47
Pages: 946-951
Peer Reviewed
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[Journal Article] IBS Club. High Prevalence of Irritable Bowel Syndrome in Medical Outpatients in Japan.2008
Author(s)
Shinozaki M, Fukudo S, Hongo M, Shimosegawa T, Sasaki D, Matsueda K, Harasawa S, Miura S, Mine T, Kaneko H, Arakawa T, Haruma K, Torii A, Azuma T, Miwa H, Fukunaga M, Handa M, Kitamori S, Miwa T
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Journal Title
J Clin Gastroenterol 42
Pages: 1010-1016
Peer Reviewed
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