Host responses to stress and progression to disease

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390191
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Nagoya University
• Principal Investigator: ISOBE Ken-ichi Nagoya University, 大学院・医学系研究科, 教授 (20151441)
• Project Period (FY): 2007 – 2009
• Keywords: ストレス / マクロファージ / 生体応答

Research Abstract

Stresses destruct tissues and wound repair processes begin. In wound healing, phagocytes such as neutrophils and macrophages clear damaged tissues, pathophysiologic processes which are also observed in atherosclerosis and autoimmune diseases. This process requires that phagocytes recognize specific surface receptors. Phagocytosis is enhanced by autoantibody-mediated opsonization of damaged tissues. We showed that Bleomycin or DSS prolong the wound healing processes and progress to systemic sclerosis and ulcerative colitis.

Research Products

• [Journal Article] Intra-bone marrow bone marrow transplantation rejuvenates the B-cell lineage in aged mice (2010)
  • Author(s): Hida D, Ishiguro N, Haneda M, Ishida Y, Suzuki H, Isobe K
  • Journal Title: Immunol Cell Biol 88(1) Pages: 87-94
  • Peer Reviewed
• [Journal Article] Antibodies to wounded tissue enhance cutaneous wound healing (2009)
  • Author(s): Nishio N, Ito S, Suzuki H, Isobe K
  • Journal Title: Immunology 128(3) Pages: 369-80
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Sakurai H, Inami Y, Tamamura Y, Yoshikai T, Sehara-Fujisawa A, Isobe K
  • Journal Title: Stem Cell Res 3(2-3) Pages: 157-69
  • Peer Reviewed
• [Journal Article] Hemoglobin induces the expression of indoleamine 2, 3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species (2009)
  • Author(s): Ogasawara N, Oguro T, Sakabe T, Matsushima M, Takikawa O, Isobe K, Nagase F
  • Journal Title: J Cell Biochem 108(3) Pages: 716-25
  • Peer Reviewed
• [Journal Article] Peptide array-based analysis of the specific IgE and IgG4 in cow's milk allergens and its use in allergy evaluation (2009)
  • Author(s): Matsumoto N, Okochi M, Matsushima M, Kato R, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H
  • Journal Title: Peptides 30(10) Pages: 1840-7
  • Peer Reviewed
• [Journal Article] Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg (2009)
  • Author(s): Shi Z, Okuno Y, Rifa'i M, Endharti AT, Akane K, Isobe K, Suzuki H
  • Journal Title: Eur J Immunol 39(8) Pages: 2106-19
  • Peer Reviewed
• [Journal Article] 免疫機能低下と老化関連疾患 (2009)
  • Author(s): 磯部健一、西尾尚美、伊藤佐知子
  • Journal Title: 日本臨床 67(7) Pages: 1327-133
• [Journal Article] Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens (2009)
  • Author(s): Matsumoto N, Okochi M, Matsushima M, Ogawa A, Takase T, Yoshida Y, Kawase M, Isobe K, Kawabe T, Honda H
  • Journal Title: J Biosci Bioeng 107(3) Pages: 324-30
  • Peer Reviewed
• [Journal Article] Injection of bleomycin in newborn mice induces autoimmune sialitis that is transferred by CD4 T cells. mmunol (2009)
  • Author(s): Ishikawa H, Ito S, Nishio N, Yuzawa Y, Matsuo S, Isobe K
  • Journal Title: Cell Biol 87(4) Pages: 351-8
  • Peer Reviewed
• [Journal Article] Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells (2009)
  • Author(s): Ishikawa H, Takeda K, Okamoto A, Matsuo S, Isobe K
  • Journal Title: J Invest Dermatol 129(7) Pages: 1688-95
  • Peer Reviewed
• [Journal Article] Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice (2009)
  • Author(s): Miura H, Shirokawa T, Isobe K, Ozaki N
  • Journal Title: Stress 12(3) Pages: 206-14
  • Peer Reviewed
• [Journal Article] IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease (2008)
  • Author(s): Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe K, Hibi T
  • Journal Title: Gut 57(12) Pages: 1682-9
  • Peer Reviewed
• [Journal Article] Overexpression of indoleamine 2, 3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model (2008)
  • Author(s): Yoshida N, Ino K, Ishida Y, Kajiyama H, Yamamoto E, Shibata K, Terauchi M, Nawa A, Akimoto H, Takikawa O, Isobe K, Kikkawa F
  • Journal Title: Clin Cancer Res 14(22) Pages: 7251-9
  • Peer Reviewed
• [Journal Article] Are CD8+CD122+ cells regulatory T cells or memory T cells? (2008)
  • Author(s): Suzuki H, Shi Z, Okuno Y, Isobe K
  • Journal Title: 69(11) Pages: 751-4
  • Peer Reviewed
• [Journal Article] CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells (2008)
  • Author(s): Rifa'i M, Shi Z, Zhang SY, Lee YH, Shiku H, Isobe K, Suzuki H
  • Journal Title: Int Immunol 20(7) Pages: 937-47
  • Peer Reviewed
• [Journal Article] Paraxial mesodermal progenitors derived from mouse embryonic stem cells contribute to muscle regeneration via differentiation into muscle satellite cells (2008)
  • Author(s): Sakurai H, Okawa Y, Inami Y, Nishio N, Isobe K
  • Journal Title: Stem Cells 26(7) Pages: 1865-73
  • Peer Reviewed
• [Journal Article] Neutrophil depletion delays wound repair in aged mice (2008)
  • Author(s): Nishio N, Okawa Y, Sakurai H, Isobe K
  • Journal Title: Age (Dordr) 30(1) Pages: 11-9
  • Peer Reviewed
• [Journal Article] Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells (2008)
  • Author(s): Shi Z, Rifa'i M, Lee YH, Shiku H, Isobe K, Suzuki H
  • Journal Title: Immunology 124(1) Pages: 121-8
  • Peer Reviewed
• [Journal Article] High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2, 3-dioxygenase in bone marrow-derived myeloid dendritic cells (2008)
  • Author(s): Hara T, Ogasawara N, Akimoto H, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F
  • Journal Title: Immunol Lett 116(1) Pages: 95-102
  • Peer Reviewed
• [Journal Article] Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2, 3-dioxygenase-expressing myeloid dendritic cells (2008)
  • Author(s): Hara T, Yamakura F, Takikawa O, Hiramatsu R, Kawabe T, Isobe K, Nagase F
  • Journal Title: J Immunol Methods 332(1-2) Pages: 162-9
  • Peer Reviewed
• [Journal Article] Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase (2008)
  • Author(s): Hiramatsu R, Hara T, Akimoto H, Takikawa O, Kawabe T, Isobe K, Nagase F
  • Journal Title: J Cell Biochem 103(1) Pages: 42-53
  • Peer Reviewed
• [Presentation] Roles of B cells to wound healing (2009)
  • Author(s): Nishio N, Ito S, Suzuki H, Isobe K
  • Organizer: II第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Immune status of the D-galactose treated aged mice (2009)
  • Author(s): Mohammad Nizam uddin, Nishio N, Ito S, Suzuki H, Isobe K
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] CD8+CD122+ reguratory T lymphocytes prevent experimental inflammatory bowel disease in mice (2009)
  • Author(s): Endharti Agustna Tri, Okuno Y, Isobe K. Suzuki H
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Establishment of an easy assay system for human CD8+CXCR3+reguratory T cells (2009)
  • Author(s): Okuno Y, Endharti Agustna Tri, Isobe K. Suzuki H
  • Organizer: 第39回日本免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] Isobe Thymic structural changes in immune aging by D-Galactose (2009)
  • Author(s): Mohammad Nizam uddin, Naomi Nishio, Sachiko Ito, Ken-ichi
  • Organizer: 第32回日本基礎老化学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-20
• [Presentation] 創傷治癒における自己組織結合抗体の役割と年齢変化 (2009)
  • Author(s): 西尾尚美、伊藤佐知子、磯部健一
  • Organizer: 第32回日本基礎老化学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-20
• [Presentation] 樋田大輔西尾尚美伊藤佐知子老化に伴うB細胞発生、分化の変化骨髄内骨髄移植による老化B細胞の若返りの可能性II (2009)
  • Author(s): 磯部健一
  • Organizer: 第32回日本基礎老化学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-19
• [Presentation] 免疫系の老化と疾患、制御の可能性 (2009)
  • Author(s): 磯部健一
  • Organizer: (シンポジウム、免疫機能の制御)第9回日本抗加齢学会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-28
• [Presentation] Bidirectional induction toward paraxial mesodermal derivatives from mouse ES cells in chemically defined medium (2008)
  • Author(s): H. Sakurai, Y. Inami, Y Tamamura K. Isobe
  • Organizer: 第31回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Analysis of the function of CD8+CD122+ refuratory T cells in tumor immunity (2008)
  • Author(s): Okuno Yusuke, Shi Zhe, Isobe Ken-ichi Suzuki Haruhik
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] 骨髄内骨髄移植による老化B細胞の若返り (2008)
  • Author(s): 樋田大輔, 羽根田正隆, 石田佳幸, 伊藤佐知子、Nizam uddin, 鈴木治彦, 磯部健一
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] Bleomycin induces autoimmune sialitis in new born mice (2008)
  • Author(s): Ishikawa Hideaki, Ito Sachiko, Kenichi Isobe
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] IL23 differentially regulates Th1/Th17 balance in ulcerative colitis and Croh's disease (2008)
  • Author(s): Kobayashi Taku, Okamoto Susumu, Hisamatsu Tadakazu, Kamada Nobuhiko, Chinenn Hirosi, Kanai Takanori, Isobe Ken-ichi, Hibi Toshifumi
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Wound healing is enhanced by autoantibodies generated in response to wounding (2008)
  • Author(s): Naomi Nishio, Sachiko Ito, Ken-ichi Isobe
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Human CD8+CXCR3+ cells have the same function as murin CD8+CD122+ reguratory T cells (2008)
  • Author(s): Suzuki Haruhiko, Shi Zhe, Okuno Yusuke, Isobe Ken-ichi
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Efficient induction of osteogenic and chondrogenic progenitors and myogenic progenitors from mouse ES cells in chemically defined medium (2008)
  • Author(s): Hidetoshi Sakurai, Yuta Inami, Naomi Nishio, Tohru Yoshikai, Ken-Ichi Isobe
  • Organizer: 2008 International Symposium on Micro-NanoMechatronics and Human Science
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-08
• [Presentation] 黒質ドーパミン神経細胞の発火様式と線条体への投射系への加齢変化 (2008)
  • Author(s): 石田佳幸、児崎達哉、磯村宣和、春光、張エイ、羽根田正隆、磯部健一
  • Organizer: 第31回基礎老化学会
  • Place of Presentation: 松本
  • Year and Date: 2008-06-13
• [Presentation] 粘膜損傷治癒における老化と好中球 (2008)
  • Author(s): 田中千恵、西尾尚美、伊藤佐知子、磯部健一
  • Organizer: 第31回基礎老化学会
  • Place of Presentation: 松本
  • Year and Date: 2008-06-13
• [Presentation] 老化に伴うB細胞発生、分化の変化骨髄内骨髄移植による老化B細胞の若返りの可能性 (2008)
  • Author(s): 樋田大輔、羽根田正隆、石田佳幸、磯部健一
  • Organizer: 第31回基礎老化学会
  • Place of Presentation: 松本
  • Year and Date: 2008-06-13
• [Presentation] 自己反応性B細胞の創傷治癒における役割と年齢変化 (2008)
  • Author(s): 西尾尚美、田中千恵、伊藤佐知子、磯部健一
  • Organizer: 第31回基礎老化学会
  • Place of Presentation: 松本
  • Year and Date: 2008-06-13
• [Presentation] Thymus involution by oral administration of DSS (2007)
  • Author(s): SASAKI Makoto, Masataka HANEDA, ISHIDA Yoshiyuki, ISOBE Ken-ichi
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Role of CD8+CD122+regulatory T cells in experimental autoimmune encepharomyelitis(II) (2007)
  • Author(s): Lee Yongho, Isobe Kenichi, Suzuki Haruhiko
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] Phosphorylation of eIF2a was upregulated in BMDC by the stimulation with LPS (2007)
  • Author(s): KIMURA Kenya, Ito Sachiko, Haneda Masataka, Isobe Ken-ichi
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] ブレオマイシンによる全身性強皮症モデル (2007)
  • Author(s): Hideaki Ishikawa, Kozue Takeda, Masataka HANEDA, ISHIDA Yoshiyuki, Ken-ichi ISOBE
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Neutrophil depletion delays wound repair in aged mice (2007)
  • Author(s): Naomi Nishio, Hidetoshi Sakurai, ISHIDA Yoshiyuki, Haneda Masataka, Ken-ichi Isobe
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] T cells in the recovery from experimental autoimmune encephalomyelitis (2007)
  • Author(s): LEE Yong Ho, Suzuki Haruhiko, Isobe Ken-ichi
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-21
• [Presentation] Bリンパ球活性化におけるプロテインフォスファターゼ1とGADD34の役割 (2007)
  • Author(s): Haneda Masataka, isobe Ken-ichi
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Deregulated activation of CD4+CD25- cells in the absence of CD8+CD122+ regulatory T cells despite the presence of CD4+CD25+ Treg in vivo (2007)
  • Author(s): SHI Zhe, Rifai Muhaimin, LEE Yong Ho, Isobe Ken-ichi、Suzuki Haruhiko
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] Functional and chemical analysis of a monoclonal antibody that preferentially react with CD8+CD122+ regulatory T cells (2007)
  • Author(s): Suzuki Haruhiko, SHI Zhe, LEE Yong Ho, Isobe, ken-ichi, Rifai MuhaiminIsobe
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] CD8+CD122+制御性T細胞に優先的に反応するモノクローナル抗体の機能的ならびに化学的解析 (2007)
  • Author(s): Suzuki Haruhiko, SHI Zhe, LEE Yong Ho, Isobe, ken-ichi, Rifai MuhaiminIsobe
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Presentation] 骨髄および胎仔肝由来ミクログリアの神経損傷時の動態について (2007)
  • Author(s): 石田佳幸, 小林朋子、ニージャム、M., 吉田憲生、羽根田正隆、磯部健一
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-20
• [Book] 免疫系の加齢変化(新老年学) (2010)
  • Author(s): 磯部健一
  • Total Pages: 169-184
• [Book] Specific serum-free conditions can differentiate mouse embryonic stem cells into osteochondrogenic and myogenic progenitors
  • Author(s): H. Sakurai, Y, Inami, N. Nishio, S. Ito, T. Yoshikai, H. Suzukiand K. Isobe
  • Total Pages: 2010
• [Patent(Industrial Property Rights)] ヒト全身性強皮症動物モデルの作製方法、ヒト全身性強皮症動物モデル及びその用途 (2007)
  • Inventor(s): 磯部健一石川英昭
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Number: 特許2007-275484
  • Filing Date: 2007-10-23