A new system of bacterial recognition and the development of a novel treatment for inflammatory bowel disease using new effective molecules

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19390194
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Asahikawa Medical College
• Principal Investigator: KOHGO Yutaka Asahikawa Medical College, 医学部, 教授 (10133183)
• Project Period (FY): 2007 – 2009
• Keywords: 炎症性腸疾 / 自然免疫 / Human defensin / Competence and sporulation factor / OCTN / バシラス菌 / 乳酸菌

Research Abstract

(1)腸管上皮の微生物認識機構の解析、(2)Paneth細胞に代表されるエフェクター細胞による抗菌物質の産生、分泌機構の解析、(3)抗菌物質による抗炎症作用の検証、の3項目について研究を行ってきた。

Research Products

• [Journal Article] Precursor Processing of Human Defensin-5 Is Essential to the Multiple Functions in vitro and in vivo (2010)
  • Author(s): Ishikawa C, Tanabe H, Maemoto A, Ito T, Watari J, Kono T, Fujiya M, Ashida T, Ayabe T, Kohgo Y.
  • Journal Title: J Innate Immunity 2 Pages: 66-76
• [Journal Article] Denatured human alpha-defensin attenuates the bactericidal activity and the stability against enzymatic digestion (2007)
  • Author(s): Tanabe H, Ayabe T, Maemoto A, Ishikawa C, Inaba Y, Sato R, Moriichi K, Okamoto K, Watari J, Kono T, Ashida T, Kohgo Y.
  • Journal Title: Biochem Biophys Res Commun 358 Pages: 349-355
• [Journal Article] The Bacillus subtilis quorum sensing molecule, CSF, contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter (2007)
  • Author(s): Fujiya M, Musch WM, Nakagawa Y, Hu S, Alverdy J, Kohgo Y, Schneewind O, Jabri B, Chang EB.
  • Journal Title: Cell Host and Microbe 1 (4) Pages: 299-308
• [Journal Article] Novel perspectives in probiotic treatment : The efficacy and unveiled mechanisms of the physiological functions
  • Author(s): Fujiya M, Kohgo Y.
  • Journal Title: Clin J Gastroenterol (in press)
• [Presentation] Competence and Sporulation Factor Derived From Bacillus Subtilis Improves Epithelial Cell Injury in Intestinal Inflammation via Immunomodulation and Cytoprotection (2010)
  • Author(s): Okamoto K, Fujiya M, Nata T, Ueno N, Inaba Y, Ishikawa C, Ito T, Moriichi K, Tanabe H, Mizukami Y, Chang EB, Kohgo Y.
  • Organizer: DDW
  • Place of Presentation: New Orleans, USA.
  • Year and Date: 20100000
• [Presentation] Lactobacillus Brevis SBC8803 Culture Supernatant Induces Cytoprotective Small Heat Shock Protein HSP27 in Human Intestinal Epithelial CaCo2/Bbe Cells by ctivating the p38 MAPK Pathway and Alleviates DSS-Induced Acute Colitis in C57BL/6 Mice. (2010)
  • Author(s): Segawa S, Fujiya M, Ueno N, Kobayashi N, Ito K, Kohgo Y.
  • Organizer: DDW
  • Place of Presentation: New Orleans, USA.
  • Year and Date: 20100000
• [Patent(Industrial Property Rights)] 腸管保護剤 (2010)
  • Inventor(s): 藤谷幹浩, 高後裕, 上野伸展, 瀬川修一, 小林直之
  • Industrial Property Rights Holder: 国立大学法人旭川医科大学, サッポロビール株式会社
  • Industrial Property Number: 特願2010-089469
  • Filing Date: 2010-04-08
• [Patent(Industrial Property Rights)] 腸管保護剤 (2008)
  • Inventor(s): 藤谷幹浩, 高後裕, 上野伸展, 瀬川修一, 小林直之
  • Industrial Property Rights Holder: 国立大学法人旭川医科大学, サッポロビール株式会社
  • Industrial Property Number: 特願2008-227537
  • Filing Date: 2008-09-04