2010 Fiscal Year Final Research Report
A study for restoration and regeneration of pancreatic exocrine function
| Project/Area Number |
19390203
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Kasei University (2008-2010)
Tokyo Metropolitan Institute of Gerontology (2007) |
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Principal Investigator |
KYOKO Miyasaka Tokyo Kasei University, 家政学部, 教授 (90166140)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIGUCHI Soichi 国立病院機構九州がんセンター, 臨床研究部, 研究員 (00280793)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKIGUCHI Soichi 国立病院機構九州がんセンター, 臨床研究部, 研究員 (00280793)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 遺伝子 / 栄養学 / タンパク質 / 内科 / ゲノム |
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| Research Abstract |
This study was designed to expect the recovery of pancreatic exocrine function from the damaged pancreas, not the regeneration from the pancreatic stem cells. Ki-ras-induced actin-interacting protein (KRAP) was originally identified in a human colon cancer cell, is conserved from fish to mammalian species. We found that the decrease and/or defect in KRAP expression resulted in pancreatic hypertrophy in mice. The level of KRAP mRNA in human cancer cell lines, in the tissues of pancreatic cancer and gallbladder cancer, and in normal pancreatic tissue did not differ to one another.
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Research Products
(53 results)
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[Journal Article] Cholecysoktinin-A receptors on retinal amacrine cells play a role in circadian photo-entrainment2008
Author(s)
Shimazoe T, Morita M, Ogiwara S, Kojiya T, Goto J, Kamakura M, Moriya T, Takiguchi S, Kono A, Miyasaka K, Funakoshi A, Ikeda M
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Journal Title
The FASEB Journal 22
Pages: 1479-1490
Peer Reviewed
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