2009 Fiscal Year Final Research Report
T helper 2 type cytokines in the gastrointestinal tissue injury
Project/Area Number |
19390204
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Research Institute, International Medical Center of Japan |
Principal Investigator |
DOHI Taeko Research Institute, International Medical Center of Japan, 部長 (60250221)
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Co-Investigator(Kenkyū-buntansha) |
IZUHARA Kenji 佐賀大学, 医学部 (00270463)
ATSUSHI Nishikawa 東京農工大学, 大学院・共生科学技術研究院, 教授 (30218127)
KAWAMURA Yuki 独立行政法人国立国際医療研究センター (10392391)
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Project Period (FY) |
2007 – 2009
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Keywords | IL-13 / IL-4 / アポトーシス |
Research Abstract |
IL-13 induced injury in the gastrointestinal epithelial cells. We proved that this effect did not required the presence of mesenchymal cells nor IL-4 receptor α,but was direct effect of IL-13 on epithelial cells. We found the IL-13 induced apoptosis in the epithelial cells by activating caspases 3, 8, and 9. TNF-α was involved in the IL-13 induced apoptosis.
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[Journal Article] TWEAK/Fn14 Pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.2009
Author(s)
Dohi T, Borodovsky A, Wu P, Shearstone JR, Kawashima R, Runkel L, Rajman L, Dong X, Scott ML, Michaelson JS, Jakubowski A, Burkly LC
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Journal Title
Gastroenterology 136
Pages: 912-923
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[Journal Article] DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer2008
Author(s)
Kawamura, YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
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Journal Title
Gastroenterology 135
Pages: 142-151
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[Journal Article] Dose-dependent, differential regulation of cytokine secretion from macrophages by fractalkine.2007
Author(s)
Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura Y.I., Toyama-Sorimachi N, Imai T, Dohi T.
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Journal Title
J. Immunol 79
Pages: 7478-7487
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[Presentation] Silencing of Sda carbohydrate-synthase gene by aberrant methylation in gastrointestinal cancer and ulcerative colitis2007
Author(s)
Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Kawamura YJ, Konishi F, Takeshita E, Miyake O, Saito Y, Kannagi R, T Dohi
Organizer
13th International Congress of Mucosal Immunology
Place of Presentation
Tokyo
Year and Date
2007-07-10
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