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2009 Fiscal Year Final Research Report

T helper 2 type cytokines in the gastrointestinal tissue injury

Research Project

  • PDF
Project/Area Number 19390204
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionResearch Institute, International Medical Center of Japan

Principal Investigator

DOHI Taeko  Research Institute, International Medical Center of Japan, 部長 (60250221)

Co-Investigator(Kenkyū-buntansha) IZUHARA Kenji  佐賀大学, 医学部 (00270463)
ATSUSHI Nishikawa  東京農工大学, 大学院・共生科学技術研究院, 教授 (30218127)
KAWAMURA Yuki  独立行政法人国立国際医療研究センター (10392391)
Project Period (FY) 2007 – 2009
KeywordsIL-13 / IL-4 / アポトーシス
Research Abstract

IL-13 induced injury in the gastrointestinal epithelial cells. We proved that this effect did not required the presence of mesenchymal cells nor IL-4 receptor α,but was direct effect of IL-13 on epithelial cells. We found the IL-13 induced apoptosis in the epithelial cells by activating caspases 3, 8, and 9. TNF-α was involved in the IL-13 induced apoptosis.

  • Research Products

    (17 results)

All 2009 2008 2007

All Journal Article (4 results) Presentation (13 results)

  • [Journal Article] TWEAK/Fn14 Pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.2009

    • Author(s)
      Dohi T, Borodovsky A, Wu P, Shearstone JR, Kawashima R, Runkel L, Rajman L, Dong X, Scott ML, Michaelson JS, Jakubowski A, Burkly LC
    • Journal Title

      Gastroenterology 136

      Pages: 912-923

  • [Journal Article] DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer2008

    • Author(s)
      Kawamura, YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
    • Journal Title

      Gastroenterology 135

      Pages: 142-151

  • [Journal Article] Incomplete synthes0is of the Sd(a)/Cad blood group carbohydrate in gastrointestinal cancer.2008

    • Author(s)
      Dohi T, Kawamura YI
    • Journal Title

      Biochim Biophys Ada 1780

      Pages: 467-471

  • [Journal Article] Dose-dependent, differential regulation of cytokine secretion from macrophages by fractalkine.2007

    • Author(s)
      Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura Y.I., Toyama-Sorimachi N, Imai T, Dohi T.
    • Journal Title

      J. Immunol 79

      Pages: 7478-7487

  • [Presentation] TWEAK/Fn14 Pathway Promotes Epithelial Cell Apoptosis after g-irradiation.2009

    • Author(s)
      Dohi T, Kawashima R, Wu P, Burkly LC
    • Organizer
      Internatinal Conference of Mucosal Immunity 2009
    • Place of Presentation
      Boston
    • Year and Date
      2009-07-06
  • [Presentation] Kawashima R, Burkly LC. Role of TWEAK (TNF-α-Like Weak Inducer of Apoptosis) in Intestinal Inflammation and Tissue Repair.2009

    • Author(s)
      Dohi T
    • Organizer
      Selected as Poster of distinction, Digestive Disease Week 2009
    • Place of Presentation
      Chicago
    • Year and Date
      2009-05-31
  • [Presentation] Inflammation-associated transcriptional silencing of Sda carbohydrate-synthase gene by DNA hypermethylation in ulcerative colitis.2008

    • Author(s)
      Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Kawamura YJ, Konishi F, Saito Y, Kannagi R, Imai K, Dohi T.
    • Organizer
      Biochemistry and Molecular Biology (BMB) 2008
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
  • [Presentation] IL-13 disrupts tight junction in the intestinal epithelial cells by modulating expression of ZO-1, ocdudin and claudin-2.2008

    • Author(s)
      Kawashima R, Kawamura YI. Toayama-Sorimachi N, Dohi T
    • Organizer
      第38回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-02
  • [Presentation] Comprehensive analysis of lectin-binding in the colitis and colitis-associated tumors in mice.2008

    • Author(s)
      V Phongsisay, Y I. Kawamura, R Kawashiama, T Dohi
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
  • [Presentation] Interleukin-13 Induces Tissue Damage with Relocation ofβ-Catenin and Modification of Cell-Cell Adhesion in the Epithelial Cells.2008

    • Author(s)
      Kawashima R, Kawamura YI, Mizutani N, Toyama-Sorimachi N, Dohi T
    • Organizer
      Digestive Disease Week 2008, Selected as Poster of distinction
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-05-20
  • [Presentation] Tweak/Fn14 Pathway: Role in the Intestinal Inflammation and Tissue Repair.2008

    • Author(s)
      Dohi T, Borodovsky A, Kawashima R, Wu P, Kawamura YI, Burkly LC
    • Organizer
      Digestive Disease Week 2008, Selected as Poster of distinction
    • Place of Presentation
      San Diego, U.S.A.
    • Year and Date
      2008-05-18
  • [Presentation] Interleukin-13 disrupts the cell-cell adhesion of intestinal epithelial cells2007

    • Author(s)
      Kawashima R, Kawamura YI, Mizutani N, Toyama-Sorimachi N Dohi T
    • Organizer
      第37回日本免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
  • [Presentation] IL-13作用の調節による消化管上皮細胞の再生促進2007

    • Author(s)
      土肥多恵子
    • Organizer
      第49回日本消化器病学会大会(JDDW)
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-19
  • [Presentation] Silencing of Sda carbohydrate-synthase gene by aberrant methylation in gastrointestinal cancer and ulcerative colitis2007

    • Author(s)
      Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Kawamura YJ, Konishi F, Takeshita E, Miyake O, Saito Y, Kannagi R, T Dohi
    • Organizer
      13th International Congress of Mucosal Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-07-10
  • [Presentation] 消化管炎症における免疫応答と組織修復2007

    • Author(s)
      土肥多恵子
    • Organizer
      神戸免疫アレルギー談話会
    • Place of Presentation
      神戸
    • Year and Date
      2007-06-14
  • [Presentation] Fractalkine Regulates TNF-alfa secretion by macrophages with induction of peroxisome proliferator-activated receptor-gamma and its ligand2007

    • Author(s)
      Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura YI, Toyama-Sorimachi N, Imai T, Dohi T
    • Organizer
      Digestive Disease Week 2007
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2007-05-23
  • [Presentation] Aberrant responses of human colonic macrophage-type cells to lipopolysaccharide in ulcerative colitis: upregulated expression of MD-2 and production of Inflammatory cytokines2007

    • Author(s)
      Kawashima R, Kawamura YI, Mizutani N, Toyama-Sorimachi N, Saito Y, Kawamura YJ, Fumio, Konishi, Dohi T
    • Organizer
      Digestive Disease Week 2007
    • Place of Presentation
      Washington D.C.
    • Year and Date
      2007-05-22

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Published: 2011-06-18   Modified: 2016-04-21  

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