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2008 Fiscal Year Final Research Report

Identification of novel regulator of atherosclerosis and development of molecular imaging technique

Research Project

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Project/Area Number 19390207
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokushima (2008)
The University of Tokyo (2007)

Principal Investigator

SATA Masataka  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (80345214)

Co-Investigator(Kenkyū-buntansha) HIRATA Yasunobu  東京大学, 医学部附属病院, 准教授 (70167609)
MOMOSE Toshimitsu  東京大学, 医学部附属病院, 准教授 (20219992)
Project Period (FY) 2007 – 2008
Keywords血管病態学 / 動脈硬化 / 脂肪
Research Abstract

動脈硬化進展と破綻に関する新規制御機構を明らかにすることを目的とした。特に、従来あまり注目されていなかった、外膜血管新生ならびに動脈周囲の脂肪組織の意義をモデル動物と手術中に得られるサンプルを用いて検討した。血管外周囲脂肪組織は、病的血管リモデリングに対して、通常防御的に機能すると考えられた。血管障害や生活習慣病によって、血管周囲脂肪組織の形質が変化し、内膜増殖や動脈硬化の病態に重要な役割を演ずることが示唆された。

  • Research Products

    (25 results)

All 2009 2008 2007

All Journal Article (19 results) (of which Peer Reviewed: 19 results) Presentation (4 results) Book (2 results)

  • [Journal Article] Fluvastatin accelerates re-endothelialization impaired by local sirolimus treatment2009

    • Author(s)
      Fukuda D, Enontoto S, Shirakawa I, Nagai R, Sata M.
    • Journal Title

      Ear J Pharmacol 612

      Pages: 87-92

    • Peer Reviewed
  • [Journal Article] When p66<ShcA> is away, mice EPCs sweetly play2009

    • Author(s)
      Sainz J, Sata M.
    • Journal Title

      Cardiovasc Res 82

      Pages: 388-389

    • Peer Reviewed
  • [Journal Article] Role of bone marrow renin angiotensin system in the pathogenesis of atherosclerosis2008

    • Author(s)
      Fukuda, D., Sata, M.
    • Journal Title

      Pharmacol Ther 21

      Pages: 70-78

    • Peer Reviewed
  • [Journal Article] The origin of the cells that contribute to neointima growth2008

    • Author(s)
      Iwata, H., Sata, M.
    • Journal Title

      Circulation 117

      Pages: 3060-3061

    • Peer Reviewed
  • [Journal Article] Contribution of circulating vascular progenitors in lesion formation and vascular healing : lessons from animal models2008

    • Author(s)
      Tanaka, K., Sata, M.
    • Journal Title

      Curr Opin Lipidol. 19

      Pages: 498-504

    • Peer Reviewed
  • [Journal Article] A critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice2008

    • Author(s)
      Fukuda, D., Sata, M., Ishizaka, N., Nagai, R.
    • Journal Title

      Arterioscler Thromb Vasc Biol 28

      Pages: 90-96

    • Peer Reviewed
  • [Journal Article] Open sesame! CXCR4 blockade recruits neutrophils into the plaque2008

    • Author(s)
      Sainz, J., Sata, M.
    • Journal Title

      Circ Res 102

      Pages: 154-156

    • Peer Reviewed
  • [Journal Article] Circulating progenitor cells contribute to neointimal formation in non-irradiated chimeric mice2008

    • Author(s)
      Tanaka, K., Sata, M., Natori, T., Kim-Kaneyama, J-R., Nose, K., Shibanuma, M., Hirata, H., Nagai, R.
    • Journal Title

      FASEB J22

      Pages: 428-436

    • Peer Reviewed
  • [Journal Article] Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice2008

    • Author(s)
      Matsumoto, M., Sata, M., Fukuda, D., Tanaka, K., Soma, M., Hirata, Y., Nagai, R.
    • Journal Title

      Atherosclerosis 197

      Pages: 524-533

    • Peer Reviewed
  • [Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction2008

    • Author(s)
      Shimazaki, M., Nakamura, K., Kii, I.Kashima, T., Amizuka, N., Li, M., Fukuda, K., Nishiyama, T, Kitajima, S., Saga, Y., Fukayama, M., Sata, M., Kudo, A.
    • Journal Title

      J Exp. Med. 205

      Pages: 295-303

    • Peer Reviewed
  • [Journal Article] Anti-arrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats2008

    • Author(s)
      Imaizumi, S., Miura, S., Nakamura, K., Kiya, Y., Uehara, Y., Zhang, B., Matsuo, Y., Urata, H., Ideishi, M., Rye, K.A., Sata, M., Saku, K.
    • Journal Title

      J Am Coll Cardiol 51

      Pages: 1604-1612

    • Peer Reviewed
  • [Journal Article] Transplantation of adipose stromal cells, but not mature adipocytes, augments ischemia-induced angiogenesis2007

    • Author(s)
      Sumi, M., Sata, M., Toya, N., Yanaga, K., Ohki, T., Nagai, R.
    • Journal Title

      Life Sci 80

      Pages: 559-565

    • Peer Reviewed
  • [Journal Article] CXCR4, a key modulator of vascular progenitor cells2007

    • Author(s)
      Sainz, J., Sata, M.
    • Journal Title

      Arterioscler Thromb Vase Biol 27

      Pages: 263-265

    • Peer Reviewed
  • [Journal Article] Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation2007

    • Author(s)
      Sahara, M., Sata, M., Morita, T., Nakamura, K., Hirata, Y., Nagai, R.
    • Journal Title

      Circulation 115

      Pages: 509-517

    • Peer Reviewed
  • [Journal Article] Mobilization of CD34-Positive bone marrow-derived cells after coronary stent implantation2007

    • Author(s)
      Inoue, T., Sata, M., Hikichi, Y., Sohma, R., Fukuda, D., Uchida, T., Shimizu, M., Komoda, H., Node, K.
    • Journal Title

      impact on restenosis. Circulation 115

      Pages: 553-561

    • Peer Reviewed
  • [Journal Article] Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis2007

    • Author(s)
      Sumi, M., Sata, M., Miura, S.I., Rye, K.A., Toya, N., Kanaoka, Y., Yanaga, K., Ohki, T., Saku, K., Nagai, R.
    • Journal Title

      Arterioscler Thromb Vase Biol 27

      Pages: 813-818

    • Peer Reviewed
  • [Journal Article] Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice2007

    • Author(s)
      Aihara, K, Azuma, H., Akaike, M., Ikeda, Y, Sata, M., Takamori, N., Yagi, S., Iwase, T., Sumitomo, Y., Kawano, H., Yamada, T., Fukuda, T., Matsumoto, T., Sekine, K., Sato, T., Nakainichi, Y., Yamamoto, Y., Yoshimura, K., Watanabe, T., Nakamura, T., Oonvzu, A., Tsukada, M., Hayashi, H., Sudo, T., Kato, S., Matsumoto, T.
    • Journal Title

      J.Glin. Invest. 117

      Pages: 1514-1526

    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker inhibits neointimal hyperplasia through regulation of smooth muscle-like progenitor cells2007

    • Author(s)
      Yamada, T., Kondo, T., Numaguchi, Y., Tsuzuki, M., Matsubara, T., Manabe, I., Sata.M., Nagai, R., Murohara, T.
    • Journal Title

      Arteriascler Thromb Vase Biol. 11

      Pages: 2363-2369

    • Peer Reviewed
  • [Journal Article] Renin-angiotensin system : a potential modulator of endothelial progenitor cells2007

    • Author(s)
      Fukuda, D., Sata, M.
    • Journal Title

      Hypertens Res. 30

      Pages: 1017-1018

    • Peer Reviewed
  • [Presentation] Endovascular injury alters adipocytokine profile of the periadventitial adipose tissue2008

    • Author(s)
      Takaoka M, Nagai R, Sata M.
    • Organizer
      American Heart Association
    • Place of Presentation
      New Orleans
    • Year and Date
      20081108-12
  • [Presentation] Eicosapentaenoic Acid Up-regulates Adiponectin Expression In Peri-adventitial Adipose Tissue And Suppresses Atherosclerotic Lesion Formation In Apoe-deficient Mice2007

    • Author(s)
      Matsumoto M
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orland
    • Year and Date
      20071104-07
  • [Presentation] Nagai R. Endovascular Injury Affects Adipocytokine Profile Of The Periadventitial Adipose Tissue2007

    • Author(s)
      Takaoka M, Sata M
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orland
    • Year and Date
      20071104-07
  • [Presentation] Acceleration of Hyperlipidemia-induced Atherosclerosis in Apolipoprotein E and Angiotensin-converting Enzyme 2 Double-Knockout Mice2007

    • Author(s)
      Sahara M, Sata M, Morita T, Hirata Y, Nagai R.
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orland
    • Year and Date
      20071104-07
  • [Book] 薬剤による血管再生血管の再生-血管再生医学の夜明け : 近づく実用化2008

    • Author(s)
      佐田政隆、(森下竜一編集)
    • Total Pages
      118-129
    • Publisher
      真興交易(株)医書出版部
  • [Book] B慢性心不全の治療21. 再生医療にエビデンスはあるのか-EBM循環器疾患の治療2008-20092007

    • Author(s)
      田中君枝、佐田政隆、三田村秀雄、山科章、川名正敏、桑島巌(編集)
    • Total Pages
      356-362
    • Publisher
      中学医学社

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Published: 2010-06-10   Modified: 2016-04-21  

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