2009 Fiscal Year Final Research Report
Research Projects to Clarify the Molecular Pathogenesis and to Develop Therapeutic or Preventive Strategy for Cardiomyopathy
Project/Area Number |
19390208
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
KIMURA Akinori Tokyo Medical and Dental University, 難治疾患研究所, 教授 (60161551)
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Project Period (FY) |
2007 – 2009
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Keywords | 心筋症 / 遺伝子変異 / サルコメア / 筋収縮 / カルシウム感受性 / Z帯 |
Research Abstract |
In this research, we have identified CARP mutations as the molecular basis of cardiomyopathy. We also found PGM1 as a binding partner of ZASP and revealed that DCM-associated ZASP mutations impaired the binding to PGM1. In addition, PGM1 was found to be localized to Z-disc upon metabolic stress of cardiomyocytes. On the other hand, we reveled that M21 enhanced the phosphorylation of M110. Finally, we demonstrated that calcium sensitizer could prevent the pathological changes in the hearts of a model mice for dilated cardiomyopathy.
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Research Products
(40 results)
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[Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function2010
Author(s)
Neelyl GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.
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Journal Title
Cell 141(1)
Pages: 142-153
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[Journal Article] Megakaryoblastic leukemia factor-1gene in the susceptibility to coronary artery disease2009
Author(s)
Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi TY, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE,, Izumi T, Kimura A.
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Journal Title
Hum Genet 126(4)
Pages: 539-547
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[Journal Article] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy2009
Author(s)
Arimura T, Bos MJ, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A.
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Journal Title
J Am Coll Cardiol 54(4)
Pages: 334-342
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[Journal Article] ANKRD-the gene encoding cardiac ankyrin repeat protein-is a novel dilated cardiomyopathy gene2009
Author(s)
Moulik M, Vatta M, Witt SH, Alora AM, Murphy RT, McKenna WJ, Boriek A, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA.
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Journal Title
J Am Coll Cardiol 54(4)
Pages: 325-333
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[Journal Article] Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy2009
Author(s)
Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A.
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Journal Title
Cardiovasc Res. 83(1)
Pages: 80-88
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[Journal Article] Role of HCN4 channel in preventing ventricular arrhythmia2009
Author(s)
Ueda K, Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A.
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Journal Title
J Hum Genet 54(2)
Pages: 115-121
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[Journal Article] HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis2009
Author(s)
Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, Tomoike H, Sakuma M, Shirato K, Takahashi M, Shibata H, Yasunami M, Chen Z, Kasahara Y, Tatsumi K, Kuriyama T, Kimura A.
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Journal Title
J Hum Genet 54(2)
Pages: 108-114
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[Journal Article] Replication of association between a chromosome 9p21 polymorphism with coronary artery disease in Japanese and Korean populations2008
Author(s)
Hinohara K, Nakajima T, Takahashi M, Hohda S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban J, Yasunami M, Park JE, Izumi T, Kimura A.
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Journal Title
J Hum Genet 53(4)
Pages: 357-359
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[Journal Article] High-density association study and nomination of susceptibility genes for hypertension in the Japanese national project2008
Author(s)
Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Hohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakamura T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H.
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Journal Title
Hum Mol Genet 17(4)
Pages: 617-627
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[Journal Article] Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy2007
Author(s)
Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A.
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Journal Title
Am J Physiol Heart Card Physiol 293(6)
Pages: H3396-H3403
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[Journal Article] Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload2007
Author(s)
Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrabdt A, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenoviv V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM.
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Journal Title
Circ Res. 101(4)
Pages: e32-e42
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[Journal Article] Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells2007
Author(s)
Knoll R, Postel R, Wang J, Kraetzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Dieter K, Gudrun K, Schaefer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nuemberg P, Schultheiss P, Schaper W, Schaper J, Bos E, Hertog JD, van Eeden F, Peters P, Hasenfuss G, Chien KR, Bakkers J.
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Journal Title
Circulation 116(5)
Pages: 515-525
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[Journal Article] A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome2007
Author(s)
Aizawa Y, Ueda K, Scornik F, Cordeiro JM, Wu Y, Desai M, Guerchicoff A, Pollevick GD, Sicouri S, Sato A, Nagata Y, Iesaka Y, Aizawa Y, Kimura A, Hiraoka M, Anzelevitch C.
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Journal Title
J Cardiovasc Electrophysiol 18(9)
Pages: 972-977
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[Journal Article] Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy2007
Author(s)
Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, Inagaki N, Hinohara K, Takahashi M, Itoh-Satoh M, Bonne G, Schwartz K, Kimura A.
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Journal Title
Biochem Biophys Res Commun 357(1)
Pages: 162-167
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[Journal Article] Long-term outcome of four Korean families with hypertrophic cardiomyopathy caused by four different mutations
Author(s)
Choi JO, You CW, Nah JC, Park JR, Lee BS, Choi BY, Cho BY, Lee SC, Park SW, Kimura A, Park JE.
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Journal Title
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[Presentation] Identification of a novel gene for hypertrophic cardiomyopathy2009
Author(s)
Arimura T, Bos JM, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Doi YL, Ackerman MJ, Kimura A
Organizer
第73回日本循環器学会学術集会
Place of Presentation
大阪
Year and Date
2009-03-22
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