2009 Fiscal Year Final Research Report
Iung repair by lung endogenous stem cells
| Project/Area Number |
19390222
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KUBO Hiroshi Tohoku University, 大学院・医学系研究科, 准教授 (20332504)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Hidemasa 埼玉医科大学, ゲノム医学研究センター, 講師 (50292123)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 呼吸器病学 |
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| Research Abstract |
We established a method to isolate lung endogenous stem cells from human and murine lungs. These stem cells had differential potentials into multi-lineage. At the same time, they had an alveolar epithelial phenotype. In murine elastase-induced lung injury model, administration of lung endogenous stem cells attenuated the injury and improved the survival ratio, suggesting a potential cell therapy to lung diseases. In addition, lung endogenous stem cells, which have a potential to differentiate into alveolar epithelium, have been discovered from adult human lungs for the first time. These cells are useful for a drug discovery.
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[Journal Article] Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells2009
Author(s)
Asada M, Yoshida M, Suzuki T, Hatachi Y, Ssasaki T, Yasuda H, Nakayama K, Nishimura H, Nagatomi R, Kubo H, Yamaya M.
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Journal Title
Antiviral Research 83
Pages: 191-200
Peer Reviewed
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[Journal Article] Identification of Pendrin as a Common Mediator for Mucus Production in Bronchial Asthma and Chronic Obstructive Pulmonary Disease2008
Author(s)
Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N, Yamaya M, Nakayama K, Kubo H, Watanabe M, Sagara H, Sugiyama K, Tanaka H, Toda S, Hayashi H, Inoue H, Hoshino T, Shiraki A, Inoue M, Suzuki K, Aizawa H, Okinami S, Nagai H, Hasegawa M, Fukuda T, Green ED, Izuhara K.
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Journal Title
J Immunol 180
Pages: 6262-6269
Peer Reviewed
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[Journal Article] Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice2007
Author(s)
Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Hori Y, Kubo H, Whitsett JA, Mak TW, Nakano T, Makazato M, Suzuki A.
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Journal Title
J Clin Invest 117
Pages: 2929-2940
Peer Reviewed
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