2009 Fiscal Year Final Research Report
Comparative studies of a clinical features and genomic analysis in patients with interstitial lung disease and drug induced lung injury
| Project/Area Number |
19390224
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOHNO Nobuoki Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (80215194)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Akihito 高知大学, 医学部, 教授 (30191513)
HATTORI Noboru 広島大学, 大学院・医歯薬学総合研究科, 准教授 (00283169)
ISHIKAWA Nobuhisa 広島大学, 大学院・医歯薬学総合研究科, 助教 (90423368)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 呼吸器病学 |
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| Research Abstract |
We elucidate a racial difference of the interstitial lung disease (ILD) by international collaborative investigation with Germany. The serum levels of KL-6 in European healthy volunteers were significantly higher than Japanese. On the other hands, serum levels of KL-6 in European ILD patients were not significantly higher than Japanese. Serum levels of KL-6 in European patients with idiopathic interstitial pneumonia (IIP) were significantly higher than European controls, and were correlated with inversely with some pulmonary function tests and BALF findings. Microarray analysis revealed that gene expression patterns clearly distinguished IIP from chronic hypersensitivity pneumonia.
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[Journal Article] Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.2008
Author(s)
Ishikawa N, Hattori N, Yokoyama A, Tanaka S, Nishino R, Yoshioka K, Ohshimo S, Fujitaka K, Ohnishi H, Hamada H, Arihiro K, Kohno N
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Journal Title
nt J Cancer 2008 122
Pages: 2612-2620
Peer Reviewed
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