2009 Fiscal Year Final Research Report
Loss of Renal Functional Reserve and Cardiovascular Events : The Key Mechanisms to Understand Cardio-Renal Connection
| Project/Area Number |
19390232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Nagoya City University |
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Principal Investigator |
KIMURA Genjiro Nagoya City University, 大学院・医学研究科, 教授 (30315874)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Michio 名古屋市立大学, 大学院・医学研究科, 准教授 (50363940)
DOHI Yasuaki 名古屋市立大学, 大学院・医学研究科, 准教授 (40305529)
OHTE Nobuyuki 名古屋市立大学, 大学院・医学研究科, 准教授 (10185332)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 高血圧学 / 心-腎連関 / 血圧日内リズム / 慢性腎臓病(CKD) / 夜間血圧 / 食塩 / RA系抑制薬 / 心血管事故 |
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| Research Abstract |
It is known as cardio-renal connection the phenomena that cardiovascular events occur frequently as a function of renal dysfunction. We have shown that as renal function deteriorates the nocturnal blood pressure is elevated and longer duration is required until nocturnal pressure falls below daytime averages. Since nocturnal hypertension is established as a strong cardiovascular risk, we propose that nocturnal hypertension and salt sensitivity play important roles in the genesis of cardio-renal connection.
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[Journal Article] Angiotensin II type 1 receptor blocker, olmesartan, restores nocturnal blood pressure decline by enhancing daytime natriuresis.2008
Author(s)
Fukuda M, Yamanaka T, Mizuno M, Motokawa M, Shirasawa Y, Miyagi S, Nishio T, Yoshida A, Kimura G
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Journal Title
J Hypertension 26
Pages: 583-588
Peer Reviewed
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