2009 Fiscal Year Final Research Report
Development of an immunotherapy against ALS model mice and analysis of the role of microglia in the pathogenesis of ALS
| Project/Area Number |
19390240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
URUSHITANI Makoto Shiga University of Medical Science, 分子神経科学研究センター, 准教授 (60332326)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Ryosuke 京都大学, 医学部, 教授 (90216771)
TATENO Minako 国立精神神経センター, 神経研究所, 室長 (50332325)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 神経病態生化学 |
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| Research Abstract |
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown etiology. The aim of this research project was to improve the vaccination and a passive immunization with a novel monoclonal antibody against mutant SOD1 using ALS model mice, and to clarify the roles of microglia in mutant SOD1-linked ALS. We found apo-form of WT SOD1 is an effective vaccine compared with mutant SOD1, which induces a protective immunity with the increase in interleukin-4 and the decrease in interferon-gamma and tumor necrosis alpha. The therapeutic effect of intrathecal infusion of one clone of the mutant SOD1-specific antibodies to slow the progression was confirmed. We also clarified the crucial role of CD14 of the microglia in extracellular SOD1 mutant-induced motor neuron death. Further development of immunotherapy for ALS can be anticipated by defining more crucial molecular target or manipulating monoclonal antibody.
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Research Products
(21 results)
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[Journal Article] Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. Proc Natl2009
Author(s)
Gros-Louis F, Andersen PM, Dupre N, Urushitani M, Dion P, Souchon F, D'Amour M, Camu W, Meininger V, Bouchard JP, Rouleau GA, Julien JP.
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Journal Title
Acad Sci U S A 106
Pages: 21777-21782
Peer Reviewed
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