Studies on hypoadiponectinemia and adipose-expressed genes for the prevention of cardiovascular diseases

2008 Fiscal Year Final Research Report

• Project/Area Number: 19390249
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Osaka University
• Principal Investigator: FUNAHASHI Tohru Osaka University, 医学系研究科, 准教授 (60243234)
• Co-Investigator(Kenkyū-buntansha): KIHARA Shinji 大阪大学, 医学系・研究科, 講師 (20332736) ; NAKAMURA Tadashi 大阪大学, 医学系・研究科, 講師 (90252668)
• Project Period (FY): 2007 – 2008
• Keywords: 動脈硬化学

Research Abstract

本研究は、現在の心血管病の基盤として脂肪細胞機能異常があると捉え、特に私達が発見し解析を進めてきた脂肪細胞由来分子、アディポネクチンに焦点をあて「低アディポネクチン血症」を一つの病態として確立し、予防医学に貢献しようと試みたものである。

Research Products

• [Journal Article] The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator (2009)
  • Author(s): Hibuse T, Maeda N, Nakatsuji H, Tochino Y, Fujita K, Kihara S, Funahashi T, Shimomura I.
  • Journal Title: Cardiovasc Res (印刷中)
• [Journal Article] Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling (2009)
  • Author(s): Nakagawa Y, Kishida K, Kihara S, Funahashi T, Shimomura I.
  • Journal Title: Biochem Biophys Res Commun 382 Pages: 183-188
  • Peer Reviewed
• [Journal Article] Osaka CAD Group.: Clinical significance of high-molecular weight form of adiponectin in male patients with coronary artery disease (2008)
  • Author(s): Komura N, Kihara S, Sonoda M, Kumada M, Fujita K, Hiuge A, Okada T, Nakagawa Y, Tamba S, Kuroda Y, Hayashi N, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Funahashi T, Matsuzawa Y
  • Journal Title: Circ Jq 72 Pages: 23-28
  • Peer Reviewed
• [Journal Article] Relationship between the serum uric acid level, visceral fat accumulation and serum adiponectin concentration in Japanese men (2008)
  • Author(s): Tamba S, Nishizawa H, Funahashi T, Okauchi Y, Ogawa T, Noguchi M, Fujita K, Ryo M, Kihara S, Iwahashi H, Yamagata K, Nakamura T, Shimomura I, Matsuzawa Y.
  • Journal Title: Intern Med 47 Pages: 1175-1180
  • Peer Reviewed
• [Journal Article] Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha (2008)
  • Author(s): Fujita K, Maeda N, Sonoda M, Ohashi K, Hibuse T, Nishizawa H, Nishida M, Hiuge A, Kurata A, Kihara S, Shimomura I, Funahashi T.
  • Journal Title: Arterioscler Thromb Vasc Biol. 28 Pages: 863-870
  • Peer Reviewed
• [Journal Article] Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea hypopnea syndrome (2008)
  • Author(s): 6. Nakagawa Y, Kishida K, Kihara S, Sonoda M, Hirata A, Yasui A, Nishizawa H, Nakamura T, Yoshida R, Shimomura I, Funahashi T.
  • Journal Title: Am J Physiol Endocrinol Metab 294 Pages: E778-E784
  • Peer Reviewed
• [Journal Article] for the Diabetes Prevention Program.: Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program (2008)
  • Author(s): Mather KJ, Funahashi T, Matsuzawa Y, Edelstein S, Bray GA, Kahn SE, Crandall J, Marcovina S, Goldstein B, Goldberg R
  • Journal Title: Diabetes 57 Pages: 980-986
  • Peer Reviewed
• [Journal Article] URB is abundantly expressed in adipose tissue and dysregulated in obesity (2008)
  • Author(s): Okada T, Nishizawa H, Kurata A, Tamba S, Sonoda M, Yasui A, Kuroda Y, Hibuse T, Maeda N, Kihara S, Hadama T, Tobita K, Akamatsu S, Maeda K, Shimomura I, Funahashi T.
  • Journal Title: Biochem Biophys Res Commun 367 Pages: 370-376
  • Peer Reviewed
• [Journal Article] Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes : The Korean atherosclerosis study (KAS) A 42-month prospective study (2008)
  • Author(s): Lim S, Koo BK, Cho SW, Kihara S, Funahashi T, Cho YM, Kim SY, Lee HK, Shimomura I, Park KS.
  • Journal Title: Atherosclerosis 196 Pages: 398-404
  • Peer Reviewed
• [Journal Article] Prognostic value of adiponectin for cardiovascular disease and mortality (2008)
  • Author(s): Dekker JM, Funahashi T, Nijpels G, Pilz S, Stehouwer CD, Snijder MB, Bouter LM, Matsuzawa Y, Shimomura I, Heine RJ.
  • Journal Title: J Clin Endocrinol Metab 93 Pages: 1489-1496
  • Peer Reviewed
• [Journal Article] Plasma adiponectin is associated with plasma brain natriuretic peptide and cardiac function in healthy subjects (2008)
  • Author(s): Ohara T, Kim J, Asakura M, Asanuma H, Nakatani S, Hashimura K, Kanzaki H, Funahashi T, Tomoike H, Kitakaze M.
  • Journal Title: Hypertens Res 31 Pages: 825-831
  • Peer Reviewed
• [Journal Article] Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals (2008)
  • Author(s): Koska J, Stefan N, Permana PA, Weyer C, Sonoda M, Bogardus C, Smith SR, Joanisse DR, Funahashi T, Krakoff J, Bunt JC.
  • Journal Title: Am J Clin Nutr. 87 Pages: 295-302
  • Peer Reviewed
• [Journal Article] Hypoadiponectinemia is associated with impaired glucose tolerance and coronary artery disease in non-diabetic men (2007)
  • Author(s): Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Sakamoto T, Yoshimura M, Kimura K, Umemura S, Ogawa H.
  • Journal Title: Circ J. 71 Pages: 1703-1709
  • Peer Reviewed
• [Journal Article] Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease (2007)
  • Author(s): Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, Sakamoto T, Horibata Y, Watanabe K, Koga H, Sugamura K, Otsuka F, Shimomura I, Ogawa H.
  • Journal Title: Atherosclerosis 194 Pages: e43-51
  • Peer Reviewed
• [Journal Article] Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model (2007)
  • Author(s): Kamada Y, Matsumoto H, Tamura S, Fukushima J, Kiso S, Fukui K, Igura T, Maeda N, Kihara S, Funahashi T, Matsuzawa Y, Shimomura I, Hayashi N.
  • Journal Title: J Hepatol 47 Pages: 556-564
  • Peer Reviewed
• [Journal Article] Reduction of visceral fat is associated with decrease in the number of metabolic risk factors in Japanese men (2007)
  • Author(s): Okauchi Y, Nishizawa H, Funahashi T, Ogawa T, Noguchi M, Ryo M, Kihara S, Iwahashi H, Yamagata K, Nakamura T, Shimomura I, Matsuzawa Y.
  • Journal Title: Diabetes Care 30 Pages: 2392-2394
  • Peer Reviewed
• [Journal Article] Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice (2007)
  • Author(s): Ohashi K, Iwatani H, Kihara S, Nakagawa Y, Komura N, Fujita K, Maeda N, Nishida M, Katsube F, Shimomura I, Ito T, Funahashi T.
  • Journal Title: Arterioscler Thromb Vasc Biol. 27 Pages: 1910-1917
  • Peer Reviewed
• [Journal Article] Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction (2007)
  • Author(s): Kojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H.
  • Journal Title: Atherosclerosis 194 Pages: 204-13
  • Peer Reviewed
• [Journal Article] The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes (2007)
  • Author(s): Comuzzie AG, Tejero ME, Funahashi T, Martin LJ, Kissebah A, Takahashi M, Kihara S, Tanaka S, Rainwater DL, Matsuzawa Y, MacCluer JW, Blangero J.
  • Journal Title: Hum Biol. 79 Pages: 191-200
  • Peer Reviewed
• [Journal Article] Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level (2007)
  • Author(s): Hiuge A, Tenenbaum A, Maeda N, Benderly M, Kumada M, Fisman EZ, Tanne D, Matas Z, Hibuse T, Fujita K, Nishizawa H, Adler Y, Motro M, Kihara S, Shimomura I, Behar S, Funahashi T.
  • Journal Title: Arterioscler Thromb Vasc Biol. 27 Pages: 635-641
  • Peer Reviewed
• [Presentation] Metabolic Syndrome & Adiponectin (2008)
  • Author(s): Funahashi T.
  • Organizer: Symposium ; US-Japan Nutrition & Metabolism Panel
  • Place of Presentation: Hanoi, Vietnam
  • Year and Date: 2008-10-30
• [Presentation] 内臓脂肪蓄積とアディポサイトカイン異常、心血管疾患 (2008)
  • Author(s): 船橋徹
  • Organizer: 第29回日本肥満学会シンポジウム
  • Place of Presentation: 大分
  • Year and Date: 2008-10-17
• [Presentation] Oxidative Stress and Organ Fibrosis in Hypoadiponectinemia (2008)
  • Author(s): 船橋徹
  • Organizer: 第51回日本糖尿病学会学術総会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-05-23
• [Presentation] Adiponectin and Metabolic Syndrome. Symposium ; Metabolic Syndrome : What is the Initial Lesion (2008)
  • Author(s): Funahashi T.
  • Organizer: 2008 Pediatric Academic Societies for Pediatric Research Meeting
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2008-05-04
• [Presentation] Aquaporin and Obeisty. Symposium ; Water (and Fat)-Logged : Aquaporin Physiology and Disease (2008)
  • Author(s): Funahashi T.
  • Organizer: 2008 Pediatric Academic Societies for Pediatric Research Meeting
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2008-05-04
• [Presentation] Metabolic Syndrome, Clinical Concept & Molecular Basis (2007)
  • Author(s): Funahashi T.
  • Organizer: Symposium ; 3rd International Conference on Food Factors for Health Promotion
  • Place of Presentation: Kyoto
  • Year and Date: 2007-11-30
• [Presentation] 教育講演 メタボリックシンドロームと脂肪細胞内分泌 (2007)
  • Author(s): 船橋徹
  • Organizer: 第44回日本臨床生理学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-21
• [Presentation] メタボリックシンドロームとアディポネクチンの心血管作用 (2007)
  • Author(s): 船橋徹
  • Organizer: 第28回日本肥満学会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-10-19
• [Presentation] Visceral Fat Accumulation and Adipocytokines (2007)
  • Author(s): Funahashi T.
  • Organizer: Symposium ; US-Japan Nutrition & Metabolism Panel
  • Place of Presentation: Minneapolis, USA
  • Year and Date: 2007-09-24
• [Presentation] Adipocytokines and Obestopathy (2007)
  • Author(s): Funahashi T.
  • Organizer: Symposium ; 10th Asian Congress of Nutrition
  • Place of Presentation: Taipei, China
  • Year and Date: 2007-09-10
• [Presentation] Role of Aquaporin Molecule in Adipose Tissue (2007)
  • Author(s): Funahashi T.
  • Organizer: Symposium ; Aquaporin and Diseases. 5th International Conference of Aquaporin
  • Place of Presentation: Nara
  • Year and Date: 2007-07-15
• [Presentation] 内臓脂肪症候群と低アディポネクチン血症 (2007)
  • Author(s): 船橋徹
  • Organizer: 第50回日本糖尿病学会学術総会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-25