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2009 Fiscal Year Final Research Report

A role of LFA-1 in the development of autoreactive Th17 cells

Research Project

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Project/Area Number 19390270
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIBUYA Kazuko  University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (00302406)

Project Period (FY) 2007 – 2009
Keywords臨床免疫学 / 自己免疫疾患 / Th17細胞 / LFA-1
Research Abstract

In the present study, we have evaluated a role of LFA-1 in the development of EAE using LFA-1-deficient mice. We demonstrate that LFA-1plays an important role in both autoantigen-specific T cell immigration to the draining lymph nodes (dLN) and development of Th17 cells, leading to the development of EAE.

  • Research Products

    (26 results)

All 2010 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (13 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice2009

    • Author(s)
      Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A.
    • Journal Title

      Proc Natl Acad Sci USA 106

      Pages: 11230-11235

    • Peer Reviewed
  • [Journal Article] NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo2009

    • Author(s)
      Lakshmikanth T., Burke S., Ali T. H., Kimpfler S., Ursini F., Ruggeri L., Capanni M., Umansky V., Paschen A., Sucker A., Pende D., Groh V., Biassoni R., Hoglund P., Kato M., Shibuya K., Schadendorf D., Anichini A., Ferrone S., Velardi A., Karre K., Shibuya A., Carbone E., Colucci F.
    • Journal Title

      J.Clin.Invest. 119

      Pages: 1151-1163

    • Peer Reviewed
  • [Journal Article] Identification of the Fca/mR Isoform Specifically Expressed in the Kidney2009

    • Author(s)
      Kurita N., Honda S., Usui K, Shimizu Y., Miyamoto A., Tahara-Hanaoka S., Shibuya K., Shibuya A.
    • Journal Title

      Mol.Immunol. 46

      Pages: 749-753

    • Peer Reviewed
  • [Journal Article] Accelerated Tumor Growth in Mice Deficient in DNAM-1 Receptor2008

    • Author(s)
      Iguchi-Manaka A., Kai H., Yamashita Y., Shibata K., Tahara-Hanaoka S., Honda S., Yasui T., Kikutani H., Shibuya K., Shibuya A.
    • Journal Title

      J.Exp.Med. 205

      Pages: 2959-2964

    • Peer Reviewed
  • [Journal Article] LFA-1 decreases the antigen dose for T cell activation in vivo2008

    • Author(s)
      Wang Y., Shibuya K., Yamashita Y., Shirakawa J., Shibata K., Kai H., Yokosuka T., Saito T., Honda S., Tahara-Hanaoka S., Shibuya A.
    • Journal Title

      Int Immunol. 20

      Pages: 1119-27

    • Peer Reviewed
  • [Journal Article] Caspase-Independent Cell Death by CD300LF (MAIR-V), an Inhibitory Immunoglobulin-Like Receptor on Myeloid Cells2008

    • Author(s)
      Can I., Tahara-Hanaoka S., Hitomi K., Nakano T., Nakahashi-Oda C., Kurita N., Honda S., Shibuya K., Shibuya A.
    • Journal Title

      J.Immunol. 180

      Pages: 207-213

    • Peer Reviewed
  • [Journal Article] Activation of neutrophils by a novel triggering immunigloblin-like receptor MAIR-IV2008

    • Author(s)
      Nakano T., Tahara-Hanaoka S., Nakahashi C., Totsuka N., Honda S., Shibuya K., Shibuya A.
    • Journal Title

      Mol.Immunol. 45

      Pages: 289-294

    • Peer Reviewed
  • [Journal Article] A critical role of LFA-1 in the development of Th17 cells and induction of experimental autoimmune encephalomyelitis2007

    • Author(s)
      Wang Y., Kai H., Chang F., Shibata K., Tahara-Hanaoka S., Honda S., Shibuya A., Shibuya K.
    • Journal Title

      Biochem Biophys Res Commun. 353

      Pages: 857-862

    • Peer Reviewed
  • [Journal Article] Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRγ chain on peritoneal macrophages2007

    • Author(s)
      Nakahashi C., Tahara-Hanaoka S., Totsuka N., Okoshi Y., Takai T., Ohkochi N., Honda S., Shibuya K., Shibuya A.
    • Journal Title

      J.Immunol. 178

      Pages: 765-770

    • Peer Reviewed
  • [Journal Article] Th1 and Type 1 Cytotoxic T Cells Dominate the Responses in Tbet Overexpression Transgenic Mice that Develop Contact Dermatitis2007

    • Author(s)
      Ishizaki K., Yamada A., Yoh K., Nakano T., Shimohata H., Maeda A., Fujioka Y, Morito N., Kawachi Y., Shibuya K., Otsuka F., Shibuya A., Takahashi S.
    • Journal Title

      J.Immunol. 178

      Pages: 605-612

    • Peer Reviewed
  • [Presentation] A critical role of DNAM-1 in the development of acute graft-versus-host disease2010

    • Author(s)
      Nabekura T.
    • Organizer
      The Keystone Symposiam
    • Place of Presentation
      USA
    • Year and Date
      2010-02-27
  • [Presentation] Novel prophylactic and therapeutic approches to GVHD with a monoclonal antobodies against DNAM-12009

    • Author(s)
      Nabekura T.
    • Organizer
      The 39^<th> Japanese Society of Immunology
    • Place of Presentation
      Osaka
    • Year and Date
      2009-12-03
  • [Presentation] 抗DNAM-1モノクローナル抗体を用いた移植片対宿主病に対する新規予防および治療法の開発2009

    • Author(s)
      鍋倉宰
    • Organizer
      第71回日本血液学会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-23
  • [Presentation] Accelerated tumor growth in mice deficient in DNAM-1 receptor2009

    • Author(s)
      Shibuya K.
    • Organizer
      Kyoto T cell Conference
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-06-01
  • [Presentation] Functional analysis of RORγt-overexpressing transgenic mice2008

    • Author(s)
      Yoh K.
    • Organizer
      The 38^<th> apanese Society of Immunology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-01
  • [Presentation] Accerelerated tumor groeth in mice deficient in DNAM-1 receptor2008

    • Author(s)
      Iguchi A.
    • Organizer
      The 38^<th> apanese Society of Immunology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-01
  • [Presentation] Involvement of DNAM-1 in development of graft-versus-host disease2008

    • Author(s)
      Nabekura T.
    • Organizer
      The ^<38>th apanese Society of Immunology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-01
  • [Presentation] A novel role of CD155 as a costimulatory molecule on CD4 helper T cells in mice2008

    • Author(s)
      Yamashita Y.
    • Organizer
      The 38^<th> apanese Society of Immunology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-01
  • [Presentation] Critical role of DNAM-1 in the development of Th1 cells2008

    • Author(s)
      Kai H.
    • Organizer
      The 38^<th> apanese Society of Immunology
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-12-01
  • [Presentation] 腫瘍免疫監視機構における免疫受容体DNAM-1の機能2008

    • Author(s)
      井口研子
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
  • [Presentation] 腫瘍免疫監視機構におけるDNAM-1の機能2008

    • Author(s)
      井口研子
    • Organizer
      KTCC
    • Place of Presentation
      京都
    • Year and Date
      2008-06-14
  • [Presentation] A critical role of DNAM-1 in tumor immunosurveillance2008

    • Author(s)
      Shibuya K.
    • Organizer
      FESEB meeting
    • Place of Presentation
      USA
    • Year and Date
      2008-06-11
  • [Presentation] A critical role of LFA-1 in the development of Th17 cells and induction of experimental autoimmune encephalomyelitis2007

    • Author(s)
      Shibata K.
    • Organizer
      The 37^<th> Japanese Society of Immunology
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-20
  • [Book] 「Th17細胞とその機能」、生体の科学、現代医学・生物学の仮説・学説2008、金原一郎記念医学医療振興財団2008

    • Author(s)
      渋谷和子
    • Total Pages
      488
    • Publisher
      医学書院
  • [Book] 「新しいヘルパーT細胞サブセット "Th17細胞"」免疫応答と免疫病態の統合的分子理解に向けて(山本一彦ほか監修)2007

    • Author(s)
      渋谷和子
    • Total Pages
      269
    • Publisher
      南山堂
  • [Remarks] ホームページ等

    • URL

      http://www.md.tsukuba.ac.jp/basic-med/immunology/immunol.index.html

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Published: 2011-06-18   Modified: 2016-04-21  

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