2009 Fiscal Year Final Research Report
A role of LFA-1 in the development of autoreactive Th17 cells
| Project/Area Number |
19390270
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SHIBUYA Kazuko University of Tsukuba, 大学院・人間総合科学研究科, 准教授 (00302406)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 臨床免疫学 / 自己免疫疾患 / Th17細胞 / LFA-1 |
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| Research Abstract |
In the present study, we have evaluated a role of LFA-1 in the development of EAE using LFA-1-deficient mice. We demonstrate that LFA-1plays an important role in both autoantigen-specific T cell immigration to the draining lymph nodes (dLN) and development of Th17 cells, leading to the development of EAE.
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[Journal Article] Enhanced humoral immune responses against T-independent antigens in Fc alpha/muR-deficient mice2009
Author(s)
Honda S, Kurita N, Miyamoto A, Cho Y, Usui K, Takeshita K, Takahashi S, Yasui T, Kikutani H, Kinoshita T, Fujita T, Tahara-Hanaoka S, Shibuya K, Shibuya A.
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 11230-11235
Peer Reviewed
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[Journal Article] NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo2009
Author(s)
Lakshmikanth T., Burke S., Ali T. H., Kimpfler S., Ursini F., Ruggeri L., Capanni M., Umansky V., Paschen A., Sucker A., Pende D., Groh V., Biassoni R., Hoglund P., Kato M., Shibuya K., Schadendorf D., Anichini A., Ferrone S., Velardi A., Karre K., Shibuya A., Carbone E., Colucci F.
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Journal Title
J.Clin.Invest. 119
Pages: 1151-1163
Peer Reviewed
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[Journal Article] LFA-1 decreases the antigen dose for T cell activation in vivo2008
Author(s)
Wang Y., Shibuya K., Yamashita Y., Shirakawa J., Shibata K., Kai H., Yokosuka T., Saito T., Honda S., Tahara-Hanaoka S., Shibuya A.
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Journal Title
Int Immunol. 20
Pages: 1119-27
Peer Reviewed
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[Journal Article] Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRγ chain on peritoneal macrophages2007
Author(s)
Nakahashi C., Tahara-Hanaoka S., Totsuka N., Okoshi Y., Takai T., Ohkochi N., Honda S., Shibuya K., Shibuya A.
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Journal Title
J.Immunol. 178
Pages: 765-770
Peer Reviewed
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[Journal Article] Th1 and Type 1 Cytotoxic T Cells Dominate the Responses in Tbet Overexpression Transgenic Mice that Develop Contact Dermatitis2007
Author(s)
Ishizaki K., Yamada A., Yoh K., Nakano T., Shimohata H., Maeda A., Fujioka Y, Morito N., Kawachi Y., Shibuya K., Otsuka F., Shibuya A., Takahashi S.
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Journal Title
J.Immunol. 178
Pages: 605-612
Peer Reviewed
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