• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2009 Fiscal Year Final Research Report

Study on the pathophysiological role of the Th2-type chemokine receptor CCR4

Research Project

  • PDF
Project/Area Number 19390277
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKinki University

Principal Investigator

YOSHIE Osamu  Kinki University, 医学部, 教授 (10166910)

Co-Investigator(Kenkyū-buntansha) HIESHIMA Kunio  近畿大学, 医学部, 准教授 (10322570)
NAKAYAMA Takashi  近畿大学, 医学部, 講師 (60319663)
NAGAKUDO Daisuke  近畿大学, 医学部, 助教 (10368293)
SHIRAKAWA Aiko  近畿大学, 医学部, 助教 (30260285)
Project Period (FY) 2007 – 2009
KeywordsCCR4 / CCL17 / CCL22 / Th2 / Treg
Research Abstract

CCR4 is a chemokine receptor selectively expressed by Th2 cells, regulatory T cells, and skin-homing T cells. We have shown a potent ther apeutic effect of a small molecule CCR4 inhibitor on Th2-induced airway inflammation in mice. We have also shown that CCR4 and its ligand MDC/CCL22 mediate immunosuppressive interactions of dendritic cells and regulatory T cells in mesenteric lymphonodes. Furthermore, human oncogenic viruses such as EBV and HTLV-1 commonly induce expression of MDC/CCL22 in infected host cells to attract Th2 cells and regulatory T cells for immunoevasion and virus propagation.

  • Research Products

    (15 results)

All 2010 2009 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (8 results)

  • [Journal Article] Tumor-infiltrating lymphocytes, particularly the balance between CD8+ T cells and CCR4+ regulatory T cells, affect the survival of patients with ortal squamous cell carcinoma.2010

    • Author(s)
      Watanebe Y, Katou F, Ohtani H, Nakayma T, Yoshie O, Hashimoto K
    • Journal Title

      Oral Surgary, Oral Medicine, Oral Pathology, Oral Radiology, and Endocrionology

    • Peer Reviewed
  • [Journal Article] Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: Functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.2009

    • Author(s)
      Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M
    • Journal Title

      J. Immunol 183

      Pages: 5608-5614

    • Peer Reviewed
  • [Journal Article] Abundant expression of CXCL9 (MIG) by stromal cells that include dendritic cells and accumulation of CXCR3+ T cells in lymphocyte-rich gastric carcinoma.2009

    • Author(s)
      Ohtani H, Jin Z, Takegawa S, Nakayama T, Yoshie O
    • Journal Title

      J. Pathol 217

      Pages: 21-31

    • Peer Reviewed
  • [Journal Article] Differential regulatory function of resting and preactivated allergen-specific CD4+CD25+ regulatory T cells in Th2-type airway inflammation.2008

    • Author(s)
      Saito K, Torii M, Ma N, Tsuchiya T, Wang L, Hori T, Nagakubo D, Nitta N, Kanegasaki S, Hieshima K, Yoshie O, Gabazza EC, Katayama N, Shiku H, Kuribayashi K, Kato T
    • Journal Title

      J. Immunol 181

      Pages: 6889-6897

    • Peer Reviewed
  • [Journal Article] NF-κB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86.2008

    • Author(s)
      Poole E, Atkins E, Nakayama T, Yoshie O, Groves I, Alcami A, Sinclair J
    • Journal Title

      J. Virol 82

      Pages: 4250-4256

    • Peer Reviewed
  • [Journal Article] Expression of CCL17 and CCL22 by latent membrane protein 1-positive tumor cells in age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder.2008

    • Author(s)
      Takegawa S, Jin Z, Nakayama T, Oyama T, Hieshima K, Nagakubo D, Shirakawa AK, Tsuzuki T, Nakamura S, Yoshie O
    • Journal Title

      Cancer Sci 99

      Pages: 296-302

    • Peer Reviewed
  • [Journal Article] Tax-inducible production of CC chemokine ligand 22 by human T cell leukemia virus type 1 (HTLV-1)-infected T cells promotes preferential transmission of HTLV-1 to CCR4-expressing CD4+ T cells.2008

    • Author(s)
      Hieshima K, Nagakubo D, Nakayama T, Shirakawa AK, Jin Z, Yoshie O
    • Journal Title

      J. Immunol 180

      Pages: 931-939

    • Peer Reviewed
  • [Presentation] T細胞依存性の好酸球性気道炎症に対するCCR4拮抗薬の作用2008

    • Author(s)
      神沼修、大友隆之、森晶夫、長久保大輔、稗島州雄、義江修、鈴木一矢、廣井隆親
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      20081029-20081031
  • [Presentation] 加齢関連EBV+B細胞リンパ増殖症における多様なケモカインの発現2008

    • Author(s)
      義江修、竹川澄男、中山隆志、白川愛子、樋口智紀、長久保大輔、重田暁子、稗島州雄、中村栄男
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20081028-20081030
  • [Presentation] CCR4を発現するATLとCTCLにおけるFra-2の異常発現2008

    • Author(s)
      中山隆志、樋口智紀、竹川澄男、長久保大輔、重田暁子、白川愛子、稗島州雄、義江修
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20081028-20081030
  • [Presentation] ケモカイン受容体CCR4とHTLV-1感染、ATL発がん2008

    • Author(s)
      義江修
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      20080908-20080710
  • [Presentation] O. Role of Fra-2/JunD heterodimer in CCR4 expression and cell proliferation in adult T-cell leukemia.2007

    • Author(s)
      Nakayama, T., Hieshima, K., Jin, Z., Nagakubo, D., Shirakawa, A., Yoshie, O
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20071120-20071122
  • [Presentation] HTLV-1のCD4+ T細胞への感染におけるケモカイン/ケモカイン受容体CCL22/CCR4の役割2007

    • Author(s)
      稗島州雄、中山隆志、白川愛子、義江修
    • Organizer
      第55回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20071021-20071023
  • [Presentation] Fra-2とJunDのヘテロダイマーはATL細胞におけるCCR4発現と細胞増殖を促進する2007

    • Author(s)
      中山隆志、稗島州雄、金哲、長久保大輔、白川愛子、山田恭暉、藤井雅寛、義江修
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20071003-20071005
  • [Presentation] HTLV-1 Tax誘導性ケモカインCCL22のHTLV-1初期感染における役割2007

    • Author(s)
      稗島州雄、中山隆志、長久保大輔、白川愛子、金哲、義江修
    • Organizer
      第66回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20071003-20071005

URL: 

Published: 2011-06-18   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi