2009 Fiscal Year Final Research Report
Basic research for inducing epithelial regeneration by bone marrow-derived epithelial cells
| Project/Area Number |
19390295
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Osaka University |
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Principal Investigator |
TAMAI Katsuto Osaka University, 医学系研究科, 准教授 (20236730)
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| Project Period (FY) |
2007 – 2009
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| Keywords | 骨髄間葉系幹細胞 / 先天性表皮水疱症 / 骨髄移植 / 骨髄由来表皮細胞 / 表皮幹細胞 |
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| Research Abstract |
We demonstrated that detached RDEB epithelia recruit platelet-derived growth factor receptor alpha (PDGFRα)-positive bone marrow cells (PDGFRα+ BMCs) via circulation, and that the PDGFRα+ BMCs contain particular population to provide epithelial cells expressing keratin 5 in the RDEB skin by differentiation of those bone marrow-derived PDGFRα-positive cells. Furthermore, the PDGFRα-positive BMCs were shown to be undifferentiated non-hematopoietic cell populations, and to reside particularly on and around surface of the bone and trabeculae in bone marrow by intravital two-photon imaging.
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Research Products
(34 results)
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[Journal Article] The compound heterozygote for new/recurrent COL7A1 mutations in a Japanese patient with bullous dermolysis of the newborn.2009
Author(s)
Hashikawa K, Hamada T, Ishii N, Fukuda S, Kuroki R, Nakama T, Yasumoto S, Tamai K, Nakano H, Sawamura D, Hashimoto T
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Journal Title
J Dermatol Sci 56
Pages: 66-8
Peer Reviewed
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[Journal Article] Development of a novel antimicrobial peptide, AG-30, with angiogenic properties.2009
Author(s)
Nishikawa T, Nakagami H, Maeda A, Morishita R, Miyazaki N, Ogawa T, Tabata Y, Kikuchi Y, Hayashi H, Tatsu Y, Yumoto N, Tamai K, Tomono K, Kaneda Y
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Journal Title
J Cell Mol Med 13
Pages: 535-46
Peer Reviewed
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[Journal Article] Bone marrow cell transfer into fetal circulation can ameliorate genetic skin diseases by providing fibroblasts to the skin and inducing immune tolerance.2008
Author(s)
Chino T, Tamai K, Yamazaki T, Otsuru S, Kikuchi Y, Nimura K, Endo M, Nagai M, Uitto J, Kitajima Y, Kaneda Y
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Journal Title
Am J Pathol 173
Pages: 803-14
Peer Reviewed
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[Journal Article] Cold shock domain protein A represses angiogenesis and lymphangiogenesis via inhibition of serum response element.2008
Author(s)
Saito Y, Nakagami H, Kurooka M, Takami Y, Kikuchi Y, Hayashi H, Nishikawa T, Tamai K, Morishita R, Azuma N, Sasajima T, Kaneda Y
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Journal Title
Oncogene 27
Pages: 1821-33
Peer Reviewed
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[Journal Article] Involvement of gamma-secretase in postnatal angiogenesis.2007
Author(s)
Hayashi H, Nakagami H, Takami Y, Sato N, Saito Y, Nishikawa T, Mori M, Koriyama H, Tamai K, Morishita R, Kaneda Y
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Journal Title
Biochem Biophys Res Commun 23;363
Pages: 584-90
Peer Reviewed
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[Journal Article] Development of Tissue-Targeting Hemagglutinating Virus of Japan Envelope Vector for Successful Delivery of Therapeutic Gene to Mouse Skin.
Author(s)
Kawachi M, Tamai K, Saga K, Yamazaki T, Fujita H, Shimbo T, Kikuchi Y, Nimura K, Nishifuji K, Amagai M, Uitto J, Kaneda Y
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Journal Title
Hum Gene Ther 18
Pages: 881-94
Peer Reviewed
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