2010 Fiscal Year Final Research Report
Study of time-functional abnormality in the inside of sensory memory in schizophrenia
| Project/Area Number |
19390299
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Fukushima Medical University (2008-2010)
Hirosaki University (2007) |
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Principal Investigator |
YABE Hirooki 福島県立医科大学, 医学部, 准教授 (60210316)
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| Co-Investigator(Kenkyū-buntansha) |
KURATA Kiyoshi 弘前大学, 大学院・医学研究科, 教授 (30170070)
MATSUOKA Takashi 福島県立医科大学, 医学部, 併任講師 (30400162)
KANEKO Sunao 弘前大学, 大学院・医学研究科, 教授 (40106852)
NIWA Shin-ichi 福島県立医科大学, 医学部, 教授 (30110703)
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| Project Period (FY) |
2007 – 2010
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| Keywords | ミスマッチ陰性電位 / MMN / 感覚記憶 / 統合失調症 / 時間統合窓 / TWI |
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| Research Abstract |
Human being has developed automatic defensive mechanism in the acoustic brain to detect the deviated sounds coming from the dangerous events. The sensory memory underlying this mechanism is reflected by the mismatch negativity(MMN) located in the vicinity of the primary auditory cortex. Our previous MMN findings strongly supports that the of preceding sounds is integrated into the sensory memory as a time-wise neural image 160-170ms epoch. The flow of time in the real world may differ from the one in the neural representation of auditory scene stored in the sensory memory, because the neutrally encoded information is free from the rule of actual time.
We found that the impaired MMN in schizophrenia might be caused by the abnormality of time-functional neural trace related to the dysfunction of temporal integration window(TWI) by measuring MMN with special TWI paradigm.(in submission)
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[Journal Article] The Potential for New Understandings of Normal and Abnormal Cognition by Integration of Neuroimaging and Behavioral Data : Not an Exercise in Carrying Coals to Newcastle2008
Author(s)
Michie P. T., Budd T. W., Fulham W. R., Hughes M. E., Jamadar S., Johnston P., Karayanidis F., Matthews N., Rasser P. E., Schall U. Thompson P. M., Todd J., Ward P. B. and Yabe H.
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Journal Title
Brain Imaging and Behavior
Volume: 2
Pages: 318-326
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