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2007 Fiscal Year Annual Research Report

子どものメンタルヘルスの大規模疫学及び脳機能研究-情動と社会性発達の観点から

Research Project

Project/Area Number 19390303
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

武井 教使  Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 特任教授 (80206937)

Co-Investigator(Kenkyū-buntansha) 土屋 賢治  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (20362189)
杉原 玄一  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (70402261)
中村 和彦  浜松医科大学, 医学部附属病院, 講師 (80263911)
宮地 泰士  浜松医科大学, 子どものこころの発達研究センター, 特任助教 (60444345)
岩田 泰秀  浜松医科大学, 医学部, 助教 (10285025)
Keywords子ども / メンタルヘルス / 疫学 / 脳発達
Research Abstract

地域社会に生活する児童、生徒のメンタルヘルスの調査の一貫として,東海地域(浜松市)の小学校,中学校,高校に在籍する,小学5年から高校3年生(n=1,412)を対象に,社会生活を送る上で重要な共感性と感情の安定性の評価を実施した。社会性、情動性の評価には,ロンドン精神医学研究所のMorris教授らが作成したSocial and Emotional Questionnaire(SEQ)(24項目,2005)を用いた。経年的発達の軌跡を調べた。SEQスコアーと学年(年齢)との間には正の相関(r=0,183P<:001)が認められた。また,性別にSEQスコアーの経年的変化をみると,男性の方が低く推移し,男子生徒の方が共感性、社会性の発達の遅れが見られた。また,SEQスコアーは,攻撃性スコアー(Aggression Questiolmair)と負の相関関係(r=-0.115 P<.001)が認められた。つまり,共感性や社会性が低いほど,攻撃性が高いことが示された。さらに,共感性や社会性が低いほど,抑うつ傾向が高いことも分かった。
一方,共感性や社会性に障害を呈する広汎性発達障害(自閉症)者に対する脳画像研究(PET画像)から,自閉症者に,情動機能にかかわるセロトニン神経系の異常を示す所見が得られた。脳全域にわたる領域で,セロトニン,トランスポーターの濃度の低下が確認された。さらに,この低下は,強迫的傾向や攻撃性と関連していた。

  • Research Products

    (13 results)

All 2007

All Journal Article (13 results) (of which Peer Reviewed: 13 results)

  • [Journal Article] Increased serum soluble L-selectin levels in unmedicated schizophrenia2007

    • Author(s)
      Iwata Y., Suzuki K., Nakamura K., Minabe Y., Takei N., Mori N.
    • Journal Title

      Schizophr Res 89(1-3)

      Pages: 154-60

    • Peer Reviewed
  • [Journal Article] Decreased serum levels of transforming growth factor-betal in patients with autism2007

    • Author(s)
      Okada K, Haslumoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Suzuki K, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 31

      Pages: 187-190

    • Peer Reviewed
  • [Journal Article] Decreased serum levels of hepatocyte growth factor in male adults with high-functioIling autism2007

    • Author(s)
      Sugihara G., Hashimoto K., Iwata Y., Nakamura k., Tsujii M., Tsuchiya K.J., Sekine Y., Yagi A., Takei N., Sugiyama T., Mori N.
    • Journal Title

      Prog Neuropsycchopharmacol Biol Psychiatr 31(2)

      Pages: 412-415

    • Peer Reviewed
  • [Journal Article] Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia2007

    • Author(s)
      Iwata Y, Nakajima M, Yamada K, Nakamura K, Sekine Y, Tsuchiya KJ, Sugihara G, Matsuzaki H, Suda S, Suzuki K, Takei N, Mori N, Iwayama Y, Takao H, Yoshikawa T, Riley B, Makoff A, Sham P, Chen R, Collier D.
    • Journal Title

      Neurosci Res 31(2)

      Pages: 412-415

    • Peer Reviewed
  • [Journal Article] Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism2007

    • Author(s)
      Sugihara G, Hashimoto K., Iwata Y., Nakamura K., Tsujii M., Tsuchiya K.J., Sekine Y., Suzuki K., Such S., MatsuzakiH., Kawai M., Minabe Y., Yagi A., Takei N., Sugiyama T., Mori N.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatr 57(2)

      Pages: 194-202

    • Peer Reviewed
  • [Journal Article] Decreased serum levels of PECAM-1 in subjects with high-functioning autism:a negative correlation with head circumference at birth2007

    • Author(s)
      Tsuchiya K.J., Hashimoto K., I wata Y., Tsujii M., Sekine Y., Sugihara G., Matsuzaki H., Suda S., Kawai M., Nakamura K., Minabe Y., Yagi A., Iyo M., Takei N., Mori N.
    • Journal Title

      Biol Psychiatry 62(9)

      Pages: 1056-8

    • Peer Reviewed
  • [Journal Article] Disruption of Reelin signaling attenuates methamphetamine-induced hy perlocomotion2007

    • Author(s)
      Matsuzaki H., Minabe Y., NakamuraK., Suzuki K., Iwata Y., Sekine Y., Tsuchiya K.J., Sugihara G, Suda S., Takei IV., Nakahara D., Haslumoto K., NairnA.C., Mori N., Sato K.
    • Journal Title

      Eur J Neurosci 25(11)

      Pages: 3376-84

    • Peer Reviewed
  • [Journal Article] SNP analyses of growth factor genes EGF,TGFbeta-1,and HGF reve al haplotypic association of EGF with autism2007

    • Author(s)
      Toyoda T., Nakamura K., Yamada K., Thanseem I, Anitha A., Suds. S., Tsujii M., Iwayama Y., Hattori E., Toyota T., Miyaclu T., Iwata Y., Suzuki K., Matsuzaki H., Kawai M., Sekine Y., Tsuchiya K., Sugihara G., Ouchi Y., Sugiyama T., Takei N., Yoshikawa T., Mori N.
    • Journal Title

      Biochenm Biophys Res Commun 360(4)

      Pages: 715-20

    • Peer Reviewed
  • [Journal Article] Genetic analyses of the brain-derived neurotrophic factor(BDNF)gene in autism2007

    • Author(s)
      Nishimura K, Nakamura K, Anitha A, Yamada K, Tsujii M, Iwayama Y, Hattori E, Toyota. T, Takei N, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Suds. S, Ouchi Y, Sugiyama T, Yoshikawa T, Mori N.
    • Journal Title

      Biochem Biophys Res Commun 356(1)

      Pages: 200-206

    • Peer Reviewed
  • [Journal Article] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism2007

    • Author(s)
      Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suds. S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N.
    • Journal Title

      Biol Psychiatry 62(3)

      Pages: 267-269

    • Peer Reviewed
  • [Journal Article] Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia2007

    • Author(s)
      Iwata Y, Suzuki K, Nakamura K, Matsuzaki H, Sekine Y, Tsuchiya KJ, Sugihara G, Kawai M, Minabe Y, Takei N, Mori N.
    • Journal Title

      Schizophr Res 89(1-3)

      Pages: 154-160

    • Peer Reviewed
  • [Journal Article] Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism2007

    • Author(s)
      Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, Suda S, Sugihara G, Matsuzaki H, Sugiyama T, Kawai M, Minabe Y, Takei N, Mori N.
    • Journal Title

      Biol Psychiatry 62(3)

      Pages: 267-269

    • Peer Reviewed
  • [Journal Article] Poor mental hea1th associated with job dissatisfaction among school teachers in Japan2007

    • Author(s)
      Nagai M, Tsuchiya KJ, Toulopoulou T, Takei N.
    • Journal Title

      J Occup Health. 49(6)

      Pages: 515-22

    • Peer Reviewed

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Published: 2010-02-04   Modified: 2016-04-21  

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