Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation

2009 Fiscal Year Final Research Report

• Project/Area Number: 19390306
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: KANBA Shigenobu Kyushu University, 大学院・医学研究院, 教授 (50195187)
• Co-Investigator(Kenkyū-buntansha): NAKABEPPU Yusaku 九州大学, 生体防御医学研究所, 教授 (30180350) ; KUROKI Toshihide 九州大学, 大学院・医学研究院, 准教授 (60215093) ; KAWASAKI Hiroaki 九州大学, 大学院・医学研究院, 准教授 (50224762) ; ONITSUKA Toshiaki 九州大学, 大学病院, 講師 (00398059) ; MAEKAWA Toshihiko 九州大学, 大学病院, 助教 (40448436) ; MOTOMURA Keisuke 九州大学, 大学病院, 助教 (60432944)
• Project Period (FY): 2007 – 2009
• Keywords: 精神薬理学 / 双極性障害

Research Abstract

Auditory evoked potential and mismatch negativity are less impaired in bipolar disorder as compared with schizophrenia. However, impairment was not statistically significant from healthy volunteers. These markers may differential bipolar disorder from schizophrenia. In addition, polymorphism of serotonin transporter genes is associated with bipolar disorder. In animal study, when given stress ; psychological or immunological, particular circuits are stimulated including hypothalamus, frontal cortex, and limbic reward system regardless the kinds of stimuli.

Research Products

• [Journal Article] Auditory gating deficit to human voices in schizophrenia: A MEG study. (2009)
  • Author(s): Hirano Y, Hirano S, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T
  • Journal Title: Schizophrenia Research 117(1) Pages: 61-7
• [Journal Article] Preattentive visual change detection as reflected by the mismatch negativity (MMN)-evidence for a memory-based process. (2009)
  • Author(s): Maekawa T, Tobimatsu S, Ogata K, Onitsuka T, Kanba S.
  • Journal Title: Neuroscience Research 65(1) Pages: 107-12
• [Journal Article] Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. (2009)
  • Author(s): Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S.
  • Journal Title: Journal of Immunology 183(12) Pages: 7778-86
• [Journal Article] Abnormal neural oscillatory activity to speech sounds in schizophrenia: a MEG study. (2008)
  • Author(s): Hirano S, Hirano Y, Maekawa T, Obayashi C, Oribe N, Kuroki T, Kanba S, Onitsuka T
  • Journal Title: Journal of Neuroscience 28 Pages: 4897-903
• [Journal Article] Inhibitory effects of aripiprazole on interferon-γ-inducedmicroglial activation via intracellular Ca2+ regulation in Vitro. (2008)
  • Author(s): Takahiro Kato, Yoshito Mizoguchi, Akira Monji, Hideki Horikawa, Sadayuki Hashioka, Shigenobu Kanba
  • Journal Title: Journal of Neurochemistry 106 Pages: 815-25
• [Journal Article] Auditory sensory gating to the human voice: A preliminary MEG study. (2008)
  • Author(s): Hirano Y, Onitsuka T, Kuroki T, Matsuki Y, Hirano S, Maekawa T, Kanba S
  • Journal Title: Psychiatry Research 163 Pages: 260-9
• [Journal Article] The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma. (2008)
  • Author(s): Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, Horikawa H, Kanba S.
  • Journal Title: Progress in Neuropsychopharmacol and Biological Psychiatry 32 Pages: 42-8
• [Journal Article] Antidepressant inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide. (2007)
  • Author(s): Hashioka S. Klegeris A, Monji A. kato T. Sawada M. McGeer PL. Kanba S
  • Journal Title: Expermental Neurology 206(1) Pages: 33-42
• [Journal Article] Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia. (2007)
  • Author(s): Hashioka S. Han YH. Fujii S. Kato T. Monji A. Utsumi H. Sawada M. Nakanishi H. Kanba S
  • Journal Title: Neurochemistry International 50 Pages: 499-506
• [Journal Article] Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro. (2007)
  • Author(s): Kato T. Monji A. Hashioka S. Kanba S
  • Journal Title: Schizophrenia Research 92 Pages: 108-115
• [Journal Article] A neurotoxic dose of methamphetamine induces gene expression of Homer 1a, but not Homer 1b or 1c, in the striatum and nucleus accumbens. (2007)
  • Author(s): Hashimoto K, Nakahara T, Yamada H, Hirano M, Kuroki T, Kanba S
  • Journal Title: Neurochem Int. 51(2-4) Pages: 227-32
• [Presentation] Association analysis of adenosine A1 receptor and dopamine D1 receptor genes with schizophrenia in the Japanese population. American Society of Human Genetics 2007 San Diago 2. Monji A et al. (2009)
  • Author(s): Gotoh L, Kawasaki H, Mitsuyasu H, et al.
  • Organizer: Are atypical antipsychotics fire extinguishers in the brain? World Congress of Biological Psychiatry
  • Place of Presentation: Paris
  • Year and Date: 20090500
• [Book] MEG脳磁図 (2007)
  • Author(s): 鬼塚俊明
  • Publisher: 先端医学社
• [Remarks] ホームページ等