2010 Fiscal Year Final Research Report
Clinical evaluation of amyloid-PET in mild cognitive impairment patients
| Project/Area Number |
19390307
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka City University |
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Principal Investigator |
MIKI Takami Osaka City University, 医学研究科, 教授 (90174002)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Hiroyuki 大阪市立大学, 大学院・医学研究科, 准教授 (90254391)
WATANABE Yasuyoshi 大阪市立大学, 大学院・医学研究科, 教授 (40144399)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Hiroshi 大阪市立大学, 大学院・医学研究科, 教授 (10159189)
NAKANISHI Aki 大阪市立弘済院附属病院, 部長 (30453137)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 認知症 / 老年精神医学 / アミロイド画像診断 |
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| Research Abstract |
Clinical significance of amyloid imaging (PIB-PET) was investigated by comparison with psychological tests and biomarkers of CSF. The cut-off value of mean cortical value based on cerebellar cortex was 1.3, and co-efficient of variation was 5.22%. Although the PIB-PET negative patients were not rare in spite of the clinical diagnosis as Alzheimer disease, the cortical value was significantly correlated with biomarkers of CSF and apoE4, and PIB-PET imaging was a powerful tool for evaluation of Alzheimer disease. For the detection of amyloid accumulation increase, longer observation period would be required.
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[Journal Article] Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography.2011
Author(s)
Y. Yamakawa, H. Shimada, S. Ataka, A. Tamura, H. Masaki, H. Naka, T. Tsutada, A. Nakanishi, S. Shiomi, Y. Watanabe, T. Miki
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Journal Title
Neurol Sci. (Epub ahead of print)
Peer Reviewed
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[Journal Article] Cortical activation during color discrimination task in macaques as revealed by positron emission tomography.2011
Author(s)
Katsuyama, N, Imamura, K, Onoe, H,, Onoe, K, Tsukada, H, Watanabe, Y
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Journal Title
Neurosci.Lett. 484
Pages: 168-173
Peer Reviewed
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[Journal Article] High Striatal Amyloid-Peptide Deposition Across Different Autosomal Alzheimer Disease Mutation Types.2009
Author(s)
VL. Villemagne, S. Ataka, T. Mizuno, WS. Brooks, Y. Wada, M. Kondo, J. Gareth, Y. Watanabe, R. Mulligan, M. Nakagawa, T. Miki, H. Shimada, H. Mori, C.C. Rowe
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Journal Title
Arch Neurol 66
Pages: 1537-1544
Peer Reviewed
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[Journal Article] A new amyloid β variant favoring oligomerization in Alzheimer-type dementia.2008
Author(s)
Tomiyama, T. Nagata, T. shimada, H. Teraoka, R. Fukushima, A. Kanemitu, H. Takuma, H Kuwano, R. Imagawa、M. Ataka, S. Wada, Y. Yoshika, E. Nishizaki, T. Watanabe, Y. Mori, H.
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Journal Title
Ann of Neurology 63
Pages: 377-387
Peer Reviewed
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[Presentation] 1231-MIBG心筋シンチグラフィーによるPiB陰性認知症の鑑別診断の検討2010
Author(s)
竹内潤, 安宅鈴香, 嶋田裕之, 河連譲治勢, 和国康弘, 蔦田強司, 塩見進, 中西亜紀, 三木隆己, 森啓, 渡邊恭良
Organizer
第29回日本認知症学会学術集会
Place of Presentation
名古屋
Year and Date
2010-11-06
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[Presentation] PiB-PET Images, Compared With MRI, FDG-PET, and IMP-SPECT imagesof a Patient With Alzheimer's Disease With Presenilin-1 Mutation (Met233Leu) Showing a New Phenotype2010
Author(s)
M. Takaya, T. Tanaka, S. Ataka, H. Shimada, T. Morihara, T. Miki, H. Kazui, M. Takeda
Organizer
ICAD 2010 (ICAD)
Place of Presentation
ハワイ(米国)
Year and Date
2010-07-12
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[Presentation] Both PiB positive and negative MCIs have similar risk of conversion to dementia.2010
Author(s)
S.Ataka, H.Shimada, J.Takeuchil, J.Kawabe, K.Takahashi, Y.Wada, A.Nakanish, T.Tsutada, S.Shiomi, H.Mori, Y.Watanabe, T.Miki
Organizer
ICAD 2010 (ICAD)
Place of Presentation
ハワイ(米国)
Year and Date
2010-07-12
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[Presentation] 11C-PIB-PET image and cognitive statement in Alzheimer's disease, mild cognitive impairment and healty aging : 1-1.5 year follow-up study.2009
Author(s)
S.Ataka H.Shimada, J.Tkeuchi, J.Kawabe, M.Shigematu, Y.Wada, A.Nakanishi, T.Tutada, S.Shiomi, H.Mori, Y.Watanabe, T.Miki
Organizer
Neuroscience
Place of Presentation
シカゴ
Year and Date
2009-10-20
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