2010 Fiscal Year Final Research Report
Molecular imaging of altered dopamine transmission in patients with schizophrenia
| Project/Area Number |
19390308
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
OKUBO Yoshiro Nippon Medical School, 大学院・医学研究科, 教授 (20213663)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Takuya 日本医科大学, 医学部, 准教授 (20246961)
TATENO Amane 日本医科大学, 医学部, 講師 (50297917)
ICHIMIYA Tetsuya 日本医科大学, 医学部, 講師 (50398864)
KOEDA Michihiko 日本医科大学, 医学部, 助教 (60434130)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 統合失調症 / 分子イメージング / ドパミン / D2受容体 |
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| Research Abstract |
Using positron emission tomography (PET) and different radioligands, we aimed to elucidate altered dopamine transmission in patients with schizophrenia. Using two different radioligands, [^<11>C]NNC112 and [^<11>C]SCH23390, we measured dopamine D1 receptor binding in patients with chronic schizophrenia and healthy controls. In patients with schizophrenia, the binding potentials of both ligands were significantly lower in the striatum and cortical regions than those of healthy controls. We measured presynaptic dopamine synthesis using PET with L-[β-^<11>C]DOPA and found that patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and that dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia. Finally, we performed PET using [^<11>C]PE2I in patients with schizophrenia and healthy subjects to investigate dopamine transporter binding. Dopamine transporter binding in the thalamus of patients with schizophrenia was significantly higher than in control subjects. There were significant correlations between dopamine transporter binding and clinical symptom scores suggesting that altered dopamine transporter binding in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia.
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[Journal Article] Contribution of dopamine D1 and D2 receptors to amygdala activity in human.2010
Author(s)
Takahashi H, Takano H, Kodaka F, Arakawa R, Yamada M, Otsuka T, Hirano Y, Kikyo H, Okubo Y, Kato M, Obata T, Ito H, Suhara T
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Journal Title
J Neurosci. 30(8)
Pages: 3043-3047
Peer Reviewed
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[Journal Article] Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophrenia.2010
Author(s)
Kosaka J, Takahashi H, Ito H, Takano A, Fujimura Y, Matsumoto R, Nozaki S, Yasuno F, Okubo Y, Kishimoto T, Suhara T
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Journal Title
Life Sci. 86(21-22)
Pages: 814-818
Peer Reviewed
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[Journal Article] Dopamine D1 receptors and nonlinear probability weighting in risky choice.2010
Author(s)
Takahashi H, Matsui H, Camerer C, Takano H, Kodaka F, Ideno T, Okubo S, Takemura K, Arakawa R, Eguchi Y, Murai T, Okubo Y, Kato M, Ito H, Suhara T
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Journal Title
J Neurosci 28
Pages: 12032-12038
Peer Reviewed
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[Journal Article] Increase in thalamic binding of [(11)C]PE2I in patients with schizophrenia: a positron emission tomography study of dopamine transporter.2009
Author(s)
Arakawa R, Ichimiya T, Ito H, Takano A, Okumura M, Takahashi H, Takano H, Yasuno F, Kato M, Okubo Y, Suhara T
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Journal Title
J Psychiatr Res. 43(15)
Pages: 1219-1223
Peer Reviewed
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[Journal Article] Regional dopamine synthesis in patients with schizophrenia using L-[beta-11C]DOPA PET.2009
Author(s)
Nozaki S, Kato M, Takano H, Ito H, Takahashi H, Arakawa R, Okumura M, Fujimura Y, Matsumoto R, Ota M, Takano A, Otsuka A, Yasuno F, Okubo Y, Kashima H, Suhara T
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Journal Title
Schizophr Res. 108(1-3)
Pages: 78-84
Peer Reviewed
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[Journal Article] Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions.2008
Author(s)
Takahashi H, Kato M, Takano H, Arakawa R, Okumura M, Otsuka T, Kodaka F, Hayashi M, Okubo Y, Ito H, Suhara T
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Journal Title
J Neurosci. 28(46)
Pages: 12032-12038
Peer Reviewed
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[Journal Article] GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit.2008
Author(s)
Asai Y, Takano A, Ito H, Okubo Y, Matsuura M, Otsuka A, Takahashi H, Ando T, Ito S, Arakawa R, Asai K,Suhara T
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Journal Title
Schizophr Res 99
Pages: 333-340
Peer Reviewed
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