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2009 Fiscal Year Final Research Report

The mechanism for fear learning concerning NMDA receptor NR2B subunit.

Research Project

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Project/Area Number 19390309
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

SHIN Ryong-moon  National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 (40443064)

Co-Investigator(Renkei-kenkyūsha) HIGUCHI Makoto  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10373359)
SUHARA Tetsuya  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, グループリーダー (90216490)
KANNO Iwao  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, グループリーダー (10360356)
Project Period (FY) 2007 – 2009
Keywords精神薬理学
Research Abstract

We show that two distinct forms of LTP could be induced at amygdale synapses with an identical stimulation protocol depending on the level of postsynaptic membrane polarization. One form of LTP, resulting from pairing of postsynaptic depolarization and presynaptic stimulation, is induced by the activation of postsynaptic NMDA receptor, while same stimulation in the absence of postsynaptic depolarization leads to LTP, which is induced by the activation of presynaptic kainite receptor. There is a defined hierarchical order, such that presynaptic LTP is suppressed when postsynaptic LTP is induced by activation of CB1 receptors by endogenous cannabinoids released from postsynaptic cell. These results describe a previously unknown mechanism for the hierarchy of co-existing forms of LTP, possibly reflecting the hierarchy of memories for the previously experienced fearful events according to their aversiveness level.

  • Research Products

    (4 results)

All 2010 2009 2008

All Presentation (4 results)

  • [Presentation] POSTECH Brain Research Center. Neuronal control on animal behaviors.2010

    • Author(s)
      辛龍文
    • Organizer
      Ghost LTP in the Amygadala 12th POSTECH Brain Winter School.
    • Place of Presentation
      Pohang University of Science & Technology (POSTECH), Pohang, South Korea
    • Year and Date
      2010-02-04
  • [Presentation] Hierachical Order of Synaptic Plasticity in Amygadala2009

    • Author(s)
      辛龍文
    • Organizer
      第115回神経科学セミナー
    • Place of Presentation
      三重大学医学部
    • Year and Date
      2009-09-14
  • [Presentation] Synaptic mechanism for Fear memory2009

    • Author(s)
      辛龍文
    • Organizer
      大学院セミ
    • Place of Presentation
      上海交通大学生命科学技術学院
    • Year and Date
      2009-02-24
  • [Presentation] Synaptic mechanism for Fear memory2008

    • Author(s)
      辛龍文
    • Organizer
      第104回神経科学セミナー
    • Place of Presentation
      三重大学医学部
    • Year and Date
      2008-01-29

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Published: 2011-06-18   Modified: 2016-04-21  

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