2009 Fiscal Year Final Research Report
Development of a microreactor for radiosynthesis of ^<18>F-probes
| Project/Area Number |
19390311
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
IWATA Ren Tohoku University, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
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| Co-Investigator(Kenkyū-buntansha) |
YANAI Kazuhiko 東北大学, 大学院・医学系研究科, 教授 (50192787)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANISHI Hiroaki 島津製作所, 基盤技術研究所, 部長 (90379595)
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| Project Period (FY) |
2007 – 2009
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| Keywords | マイクロリアクター / 標識合成 / フッ素-18 / 電気化学的濃縮 / PET |
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| Research Abstract |
An automated system was developed for concentration of aqueous ^<18>F-fluoride produced in ^<18>O-water with a cyclotron. It was electrochemically trapped in a disposable microflow cell chip and then released as a complex with K+-K.222 in a small portion of an aprotic solvent (<60μL) such as acetonitrile and DMSO. Thus, the concentrated solution was mixed with a precursor solution followed by passing through a heated microchannel to synthesize ^<18>F-FDG, FLT and FMISO. Reaction time, temperature and solvent were examined for optimizing ^<18>F-substitution reactions. It was observed that microreactor radiosynthesis was very rapid and efficient as reported.
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Research Products
(49 results)
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[Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET2010
Author(s)
N. Okamura, Y. Shiga, S. Furumoto, M. Tashiro, Y. Tsuboi, K. Furukawa, K. Yanai, R. Iwata, H. Arai, Y. Kudo, Y. Itoyama, K. Doh-Ura
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Journal Title
Eur.J.Nucl.Med.Mol.Imag. (印刷中)
Peer Reviewed
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[Journal Article] Imaging of hypoxic lesion in glioma patients by PET with [^<18>F]FRP-170, a new ^<18>F-labeled 2-nitroimidazole analog2010
Author(s)
I. Shibahara, T. Kumabe, M. Kanamori, R. Saito, Y. Sonoda, M. Watanabe, R. Iwata, S. Higano, K. Takanami, Y. Takai, T. Tominaga
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Journal Title
Peer Reviewed
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[Journal Article] Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease2009
Author(s)
M. Waragai, N. Okamura, K. Furukawa, M. Tashiro, S. Furumoto, Y. Funaki, M. Kato, R. Iwata, K. Yanai, Y. Kudo, H. Arai
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Journal Title
J.Nuerol.Sci. 285巻
Pages: 100-108
Peer Reviewed
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[Journal Article] Brain histamine H_1 receptor occupancy of orally administrated antihistamines, bepotastine and diphendydramine, measured by PET with ^<11>C-doxepin2008
Author(s)
M. Tashiro, X. Duan, M. Kato, M. Miyake, S. Watanuki, Y. Ishikawa, Y. Funaki, R. Iwata, M. Itoh, K. Yanai
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Journal Title
Brit.J.Clin.Pharmacol. 65巻
Pages: 811-821
Peer Reviewed
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[Journal Article] First achievement of less than 1 mm FWHM resolution in practical semiconductor animal PET scanner2007
Author(s)
K. Ishii, Y. Kikuchi, S. Matsuyama, Y. Kanai, K. Kotani, T. Ito, H. Yamazaki, Y. Funaki, R. Iwata, M. Itoh, K. Yanai, J. Hatazawa, N. Itoh, N. Tanizaki, D. Amano, M. Yamada, T. Yamaguchi
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Journal Title
Nucl.Instr.Meth.Phys.Res. A576巻
Pages: 435-440
Peer Reviewed
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[Journal Article] Initial evaluation of dynamic human imaging using ^<18>F-FRP170 as a new PET tracer for imaging hypoxia2007
Author(s)
K. Kaneta, Y. Takai, R. Iwata, T. Hakamatsuka, H. Yasuda, K. Nakayama, Y. Ishikawa, S. Watanuki, S. Furumoto, Y. Funaki, E. Nakata, K. Jingu, M. Tsujitani, M. Itoh, H. Fukuda, S. Takahashi, S. Yamada
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Journal Title
Ann.Nucl.Med. 21巻
Pages: 101-107
Peer Reviewed
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[Presentation] [^<11>C]BF-227 PET Study in Protein Conformational Diseases2009
Author(s)
N. Okamura, S. Furumoto, M. Tashiro, Y. Funaki, A. Kikuchi, Y Shiga, K. Furukawa, H. Arai, K. Doh-Ura, R. Iwata, K. Yanai, Y. Kudo
Organizer
欧州核医学会
Place of Presentation
バルセロナ
Year and Date
20091010-20091014
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[Presentation] マイクロリアクターを用いた[^<18>F]SFBのOne-flow合成法の開発2009
Author(s)
木村寛之, 戸松賢治, 河嶋秀和, 中西博昭, 小関英一, 斎木秀和, 藤山陽一, 岩田錬, 久下祐司, 小野正博, 佐治英郎
Organizer
第49回日本核医学会学術総会
Place of Presentation
旭川
Year and Date
2009-10-01
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[Presentation] [^<11>C]BF-227を用いた脳内アミロイド蓄積に関する定量的検討2007
Author(s)
田代学, 岡村信行, 熊谷和明, 古本祥三, 船木善仁, 木村雄一, 石渡喜一, 岩田錬, 工藤幸司, 荒井啓行, 谷内一彦
Organizer
第47回日本核医学会学術総会
Place of Presentation
仙台
Year and Date
2007-11-05
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