Development of pre-synaptic cholinergic nervous system imaging agent for Alzheimer's disease early diagnosis

2009 Fiscal Year Self-evaluation Report

• Project/Area Number: 19390316
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: SHIBA Kazuhiro Kanazawa University, 学際科学実験センター, 教授 (40143929)
• Project Period (FY): 2007 – 2010
• Keywords: アセチルコリントランスポーター / 分子イメージング / SPECT / PET

Research Abstract

アルツハイマー病の神経化学的変化を鋭敏に捉え可視化することにより、早期画像診断を行う方法を確立することを目的とする。これにより、主症状が現れる前の治療ができアルツハイマー病患者のQOLの改善が可能となる。さらに、根本治療法が開発された場合の治療効果判定も可能となる。上記目的を達成するために、アルツハイマー病の早期に変化があるとされるコリン作動性神経系に着目し、アセチルコリントランスポーター(VAChT)や合成酵素を可視化するためのSPECT用及びPET用の分子イメージング剤の開発を行い、アルツハイマー病モデル動物を用い、アルツハイマー病の早期診断の可能性を検討する。

Research Products

• [Journal Article] The potential of (-)-o-[11C] methyl vesamicol for diagnosing cholinergic deficit dementia (2009)
  • Author(s): Shiba, K., Nishiyama, S., Tsukada, H., Ishiwata, K., Kawamura, K., Ogawa, K., Mori, H.
  • Journal Title: Synapse Vol.63 Pages: 167-171
  • Peer Reviewed
• [Journal Article] A Change of in Vivo Characteristics Depending on Specific Activity of Radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol [(+)-pIV] as a Ligand for Sigma Receptor Imaging (2008)
  • Author(s): Akhter, N., Shiba, K., Ogawa, K., Tsuji, S., Kinuya, S., Nakajima, K, Mori, H.
  • Journal Title: Nucl.Med.Biol. Vol.35 Pages: 29-34
  • Peer Reviewed
• [Journal Article] Rapid Reduction of σ1-Receptor Binding and 18F-FDG Uptake in Rat Gliomas After In vivo Treatment with Doxorubicine (2007)
  • Author(s): Waarde, AV., Shiba, K., de Jong, JR., Ishiwata, K., Dierckx, RA, Elsinga, PH.
  • Journal Title: J Nucl.Med. Vol.48 Pages: 1320-1326
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of fluorine-18-labeled SA4503 as a selective sigmal receptor ligand for positron emission tomography (2007)
  • Author(s): Kawamura, K., Tsukada, H., Shiba, K., Tsuji, C., Harada, N., Kimura, Y, Ishiwata, K.
  • Journal Title: Nucl.Med.Biol. Vol.34 Pages: 571-577
  • Peer Reviewed
• [Presentation] Ligand for vesicular acetylcholine transporter (2009)
  • Author(s): Shiba. K
  • Organizer: 2009 BIO INTERNATIONAL CONVENTION" (BIO2009)
  • Place of Presentation: Atlanta (USA)
  • Year and Date: 20090518-20090521
• [Presentation] In-vivo characteristics of high and low specific activity radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol [(+)-pIV] for imaging sigma-1 receptor in brain (2007)
  • Author(s): Akhter. N, Shiba. K, Ogaw. K, Kinuya. S, Nakajima. K, Mori. H
  • Organizer: INTERNATIONAL CONFERENCE ON RADIOPHARMACEUTICAL THERAPY (ICRT-2007)
  • Place of Presentation: Ulaanbaatar (Mongolia)
  • Year and Date: 20070903-20070907
• [Presentation] Potential usefulness of the D2R reorter gene imaging by IBF as a gene therapy monitoring for cerebellar disorder (2007)
  • Author(s): Shiba. K, Ogawa. K, Torashima. T, Hirai. H, Akhter. N, Kinuya. S, Mori. H
  • Organizer: 54th SNM annual meeting of the Society of Nuclear Medicine
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 20070602-20070606
• [Presentation] ^<18>F-labeled SA4503 as a selective sigmal receptor ligand for PET (2007)
  • Author(s): Kawamura. K, Tsukada. H, Shiba. K, Tsuji. C, Harada. N, Kimura. Y, Ishiwata. K
  • Organizer: A preconference Summer School to BRAIN07 and BRAINPET07, under the auspices of the International Society for Cerebral Blood Flow and Metabolism
  • Place of Presentation: Kobe (Japan)
  • Year and Date: 20070517-20070519
• [Presentation] トランスポーター分子イメージングを利用した脳神経変性疾患の早期診断法に関する研究 (2007)
  • Author(s): 柴和弘
  • Organizer: トランスポーター研究会北陸地方部
  • Place of Presentation: 射水市(富山県)
  • Year and Date: 2007-09-29