2009 Fiscal Year Final Research Report
Radiation Effect on Invasion, Metastatic and Angiogenesis Potential of Cancer
| Project/Area Number |
19390320
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
TESHIMA Teruki Osaka University, 大学院・医学系研究科, 教授 (40136049)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUURA Nariaki 大阪大学, 大学院・医学系研究科, 教授 (70190402)
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| Project Period (FY) |
2007 – 2009
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| Keywords | がん / 転移浸潤 / 血管新生 / X線 / 炭素イオン線 / 腫瘍血管標的薬 / タンパク質遺伝子 |
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| Research Abstract |
Carbon ion beams suppressed the potential of invasion and migration of tumor cell lines more significantly than X-ray. Furthermore, the expression of anillin and the activation of RhoA were decreased on these cells. Thus, carbon ion beams irradiation suppressed the invasion and migration of cancer cells via decreasing expression of anillin and inactivation of RhoA. The combination with an antimicrotubule agent TZT-1027 and X-ray irradiation showed synergistic effects of anti-angiogenesis.
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